Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A novel Approach for High Rate Production of IR to IR Up-converting Nano-particles

    SBC: UES, Inc.            Topic: AF11BT24

    ABSTRACT: Phosphor materials are currently being utilized in a wide variety of applications. The requirements for phosphors have become more and more stringent with smaller and smaller particles being required. In the Phase I program UES Inc. in collaboration with Penn State University has demonstrated the feasibility of a few approaches for high rate production of high efficiency IR to IR up-con ...

    STTR Phase II 2014 Department of DefenseAir Force
  3. Active Control of a Scramjet Engine

    SBC: Ahmic Aerospace LLC            Topic: AF15AT19

    Scramjet engines are designed to operate across a wide Mach number range and typically incorporate isolator sections to provide sufficient back-pressure margin and prevent unstart. As military requirements become increasingly demanding, an active, closed-loop control system is necessary to maintain engine stability and power output. During Phase I, key components of a scramjet control system were ...

    STTR Phase II 2016 Department of DefenseAir Force
  4. Advanced Optical Diagnostics/Modeling Platform for Plasma Assisted Combustion in Vitiated Air

    SBC: Spectral Energies, LLC            Topic: AF13AT04

    ABSTRACT: Modern gas-turbine engines designs for the next-generation warfighter need to reduce exhaust gas temperatures to reduce effective thermal footprint thereby improving the mission capability. In such situations, high-altitude engine operation is often limited by the overall combustion efficiency, lean flame blow out (LBO) limit, and combustion instabilities that results in narrower opera ...

    STTR Phase I 2014 Department of DefenseAir Force
  5. Antibody targeting of ADAM for treatment of triple negative breast cancer

    SBC: Adecto Pharmaceuticals, Inc.            Topic: NCI

    DESCRIPTION provided by applicant Triple negative breast cancers TNBCs account for of breast cancer deaths and lack targeted therapies Drs Sonenshein Mineva and Romagnoli and their co workers recently identified the non essential cell surface protein ADAM A Disintegrin and Metalloprotease as a pivotal promoter of breast tumor growth and metastasis and validated it as a target o ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Aptamer-based Nanofunctionalized OFET Biosensors

    SBC: Cornerstone Research Group, Incorporated            Topic: AF14AT11

    ABSTRACT: Researchers are identifying new biomarkers to help monitor, diagnose, and treat growing threats to the human body and enhance human performance. Recent sensor work combining biorecognition elements with field effect transistors (bio-FETs) has been shown sensitive and selective to biomarkers in the picomolar range with continuous detection; however device-to-device performance variability ...

    STTR Phase II 2016 Department of DefenseAir Force
  7. Brain penetrant Hsp90 inhibitors for Alzheimer's disease

    SBC: YUMA THERAPEUTICS CORPORAITON            Topic: NIA

    DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Cell Therapy for the Treatment of Acute Respiratory Distress Syndrome

    SBC: ATHERSYS, INC.            Topic: NIAAA

    DESCRIPTION provided by applicant This is a resubmission of a Phase I Phase II Fast Track application for the clinical use of MultiStem in patients with acute respiratory distress syndrome ARDS ARDS is defined as acute onset hypoxemia bilateral radiographic pulmonary infiltrates and lack of atrial pressure hypertension A novel and exiting possibility is the use of cells as part of the ther ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Coils for Human Whole Body Imaging at 7T

    SBC: LIFE SERVICES L.L.C.            Topic: NIBIB

    DESCRIPTION provided by applicant For this Phase II STTR proposal the investigators plan to develop and commercialize the radiofrequency RF coil technology to make T body MRI possible and to translate this new technology to vastly improve T clinical MRI as well In the Phase I project leading to this proposal all specific aims were accomplished to demonstrate the feasibility of safely an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Compact CMOS-Compatible Optical Transceiver

    SBC: Physical Sciences Inc.            Topic: AF14AT13

    ABSTRACT: Close integration of photonic devices with silicon complementary metal-oxide semiconductor (CMOS) electronics can yield significant performance improvements in many applications. The recent development of novel integrated structures in silicon including waveguides, resonators, and photodetectors will enable dramatic reductions in size, weight, and power for components implementing compl ...

    STTR Phase I 2014 Department of DefenseAir Force
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