Award Data

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

DESCRIPTION provided by applicant For this Phase II STTR proposal the investigators plan to develop and commercialize the radiofrequency RF coil technology to make T body MRI possible and to translate this new technology to vastly improve T clinical MRI as well In the Phase I project leading to this proposal all specific aims were accomplished to demonstrate the feasibility of safely an ...

DESCRIPTION provided by applicant The thalassemias and sickle cell disease are serious genetic blood diseases which are WHO designated as a growing global health burden The disorders decrease production or alter structure of the b chain of adult hemoglobin A and are characterized by anemia chronic organ damage and early mortality HbF is another type of normal hemoglobin which is suppres ...

ABSTRACT: Physical Sciences Inc. (PSI) and the University of Tennessee Space Institute (UTSI) will develop an innovative system to measure and control the cryodeposit layer thickness that develops on cold (~20 K) surfaces in cryogenic radiometric calibration chambers. Currently removing the cryo-layer involves a lengthy process that warms the entire cryo-system to desorb the cryo-layer that incr ...

DESCRIPTION provided by applicant Non alcoholic steatohepatitis NASH is characterized by fatty changes in the liver with inflammation and hepatocellular injury that in advanced stages leads to fibrosis and cirrhosis and high mortality rates NASH is frequently associated with other common metabolic abnormalities such as insulin resistance and visceral obesity Liver transplantation is curren ...

DESCRIPTION provided by applicant The proposed project is designed to fill an important yet unmet need by developing an online education program using simulations and scenario based learning to reach all public health and safety emergency responders and students responsible for emergency planning with and response for individuals with disabilities In Phase II the applicant organization P ...

DESCRIPTION provided by applicant The declining cost of whole exome sequencing WES is nearing the point at which the spread of WES into clinical practice will be limited largely by the cost of interpreting the results and comparing them to the patientandapos s clinical findings This project builds on our demonstrated capability to reduce this interpretation cost by pairing our diagnostic sof ...

ABSTRACT: This Phase II STTR research proposal aims to demonstrate an antenna coupled phase modulator based on an Electro-optic (EO) polymer refilled slot photonic crystal waveguide (PCW) for operation in the Q band. The goal is to detect field strengths of 100uW/m^2 in an Intensity Modulation Direct Detection (IMDD) scheme using subwavelength antennas. The EO polymer is the SEO125 provided by Dr ...

ABSTRACT: In this program, Omega Optics, Inc., in collaboration with the University of Michigan Ann Arbor and the University of Texas at Austin, proposes to develop integrated photonic devices by using a combination of high-rate R2R nanoimprint lithography (R2RNIL) and R2R ink-jet printing. Patterning of photonic devices with sub-wavelength (