Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel Technology to Produce Yb:Sr-FAP Transparent Laser Host Ceramics in Non-Isotropic Materials

    SBC: Texas Biochemicals Incorporated            Topic: AF14AT26

    ABSTRACT: To fabricate transparent ceramics composed of anisotropic laser gain media, the crystal orientations of micro-domains should be aligned identically. Current method involve application of high magnetic field. Texas Biochemicals Inc. recently developed a novel technology to produce faceted hexagonal prism c axis oriented Yb: Sr-FAP [Yb: Sr5(PO4)3F nanocrystallites and sintered into transp ...

    STTR Phase I 2014 Department of DefenseAir Force
  3. Brain penetrant Hsp90 inhibitors for Alzheimer's disease

    SBC: YUMA THERAPEUTICS CORPORAITON            Topic: NIA

    DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  4. Coils for Human Whole Body Imaging at 7T

    SBC: LIFE SERVICES L.L.C.            Topic: NIBIB

    DESCRIPTION provided by applicant For this Phase II STTR proposal the investigators plan to develop and commercialize the radiofrequency RF coil technology to make T body MRI possible and to translate this new technology to vastly improve T clinical MRI as well In the Phase I project leading to this proposal all specific aims were accomplished to demonstrate the feasibility of safely an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  5. Compact CMOS-Compatible Optical Transceiver

    SBC: Physical Sciences Inc.            Topic: AF14AT13

    ABSTRACT: Close integration of photonic devices with silicon complementary metal-oxide semiconductor (CMOS) electronics can yield significant performance improvements in many applications. The recent development of novel integrated structures in silicon including waveguides, resonators, and photodetectors will enable dramatic reductions in size, weight, and power for components implementing compl ...

    STTR Phase I 2014 Department of DefenseAir Force
  6. Decision Making under Uncertainty for Dynamic Spectrum Access

    SBC: INFOBEYOND TECHNOLOGY, LLC            Topic: AF13AT02

    ABSTRACT: Due to scarcity of spectrum, Dynamic Spectrum Access (DSA) becomes a needed technology to improve the utilization of electromagnetic spectrum for DoD satellite communication. However, current DSA approaches are developed for terrestrial communications without addressing the unique challenges for SATCOM environments such as error-prone spectrum sensing, high mobility, and large coverage. ...

    STTR Phase I 2014 Department of DefenseAir Force
  7. Development of a clinical hemoglobin modulator

    SBC: Phoenicia Biosciences, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant The thalassemias and sickle cell disease are serious genetic blood diseases which are WHO designated as a growing global health burden The disorders decrease production or alter structure of the b chain of adult hemoglobin A and are characterized by anemia chronic organ damage and early mortality HbF is another type of normal hemoglobin which is suppres ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  8. Development of an Innovative System for Cryodeposit Mitigation and Redmediation

    SBC: Physical Sciences Inc.            Topic: AF12BT10

    ABSTRACT: Physical Sciences Inc. (PSI) and the University of Tennessee Space Institute (UTSI) will develop an innovative system to measure and control the cryodeposit layer thickness that develops on cold (~20 K) surfaces in cryogenic radiometric calibration chambers. Currently removing the cryo-layer involves a lengthy process that warms the entire cryo-system to desorb the cryo-layer that incr ...

    STTR Phase II 2014 Department of DefenseAir Force
  9. Development of PAR2 Inhibitors for the Treatment of Nonalcoholic steatohepatitis

    SBC: OASIS PHARMACEUTICALS, LLC            Topic: NIDDK

    DESCRIPTION provided by applicant Non alcoholic steatohepatitis NASH is characterized by fatty changes in the liver with inflammation and hepatocellular injury that in advanced stages leads to fibrosis and cirrhosis and high mortality rates NASH is frequently associated with other common metabolic abnormalities such as insulin resistance and visceral obesity Liver transplantation is curren ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Development, Usability Testing, and Effectiveness Evaluation of the Wraparou

    SBC: ACCOUNTABILITY SOLUTIONS, INC.            Topic: 104

    DESCRIPTION provided by applicant The purpose of this Phase II Small Business Technology Transfer STTR project is to complete development and evaluate usability and effectiveness of the Wraparound Team Monitoring System Wrap TMS a web based electronic behavioral health information system EBHIS for the most widely implemented care coordination model in childrenandapos s behavioral healt ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
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