Award Data

DESCRIPTION (provided by applicant): The current Phase I SBIR Grant application by Inotek Pharmaceuticals Corporation proposes to test the antinociceptive effect of a novel A1 receptor agonist in rat models. As preliminary data we present evidence in

PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

DESCRIPTION (provided by applicant): An estimated 5.4 million Americans had Alzheimer's disease in 2012 and a 50% increase in this number is expected by 2030. The majority of these patients (70%) will live at home where they receive 75% of their care frominformal caregivers, unpaid individuals such as family members, friends, and neighbors. These caregivers provide valuable services, often a ...

DESCRIPTION (provided by applicant): Increased stiffness of large central conduit vessels has recently emerged as an important risk factor for cardiovascular disease. Abnormalities in conduit vessel stiffness are highly prevalent and are associated wi

Chemotherapeutic dosing has traditionally been empiric, with all patients receiving the same dose adjusted for body surface area (BSA). Unfortunately, while this may be adequate for the average person, it can be inappropriate for the majority of patien

DESCRIPTION (provided by applicant): We propose to develop a compact, cost-effective Traveling Wave Tube (TWT) amplifier at 263 GHz with 50 W of peak power, 5 W of continuous wave power and 5% instantaneous bandwidth for application in Dynamic Nuclear Polarization (DNP) enhanced solid-state and solution-state NMR and Electron Paramagnetic Resonance (EPR) spectroscopy. With DNP, the inherently smal ...

DESCRIPTION (provided by applicant): We propose the development of a completely wireless, "smart" surface electromyographic (EMG) system. The multi-channel digital system will provide reliable, accurate, and noninvasive monitoring of the neuromuscula

DESCRIPTION (provided by applicant): Retransfusion of a patient's shed blood during cardiopulmonary bypass is attractive since it reduces the need for allogeneic transfusion, minimizes cost, and decreases transfusion related morbidity. Heterologous transfusions are linked to increased long term mortality after cardiac surgery. However, brain damage after cardiac surgery with retransfusion of ...

We propose to design, develop, and evaluate a system for Acquiring representations of Meta-information to Enhance Battlespace Awareness (AMEBA). AMEBA aids the warfighter by providing representations of meta-information, or characteristics of information such as uncertainty, staleness, etc. that aid decision-making and are not typically provided. Under Phase I, we demonstrated the feasibility of ...

Of approximately 4 million live births in the United States in year 2000, 11.6 percent or about 471,000 infants were born less than 37 weeks gestation (Martin et al.). Preterm infants may spend days or weeks in a neonatal intensive care unit (NICU), where