Award Data

DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

In this STTR, OASIS Inc, with partners the Massachusetts Institute of Technology (MIT) and the Applied Physics Laboratory University of Washington (APL-UW) proposes to develop an innovative, interactive submarine acoustic counter detect TDA for use by the Submarine Mission Planners, within the AN/BYG-1. Communicating the environmental and tactical uncertainty is of primary importance when present ...

Typical acoustic materials rely on embedded continuous mass layer to attenuate low frequency sound. Energy from low frequency sound is not effectively mitigated with these materials unless a substantial amount of mass is added. Thus, standard materials for low frequency noise control tend to be heavy, expensive and difficult to install. A new technology is being developed that utilizes optimized ...

Modern control theory offers mathematically rigorous and powerful solutions to many dynamic systems. Its limitations are that the classes of dynamic systems covered by the theory are limited to linear systems or certain well-structured nonlinear systems, and the adaptation of the controllers are often slow if the controller parameters are far away from their desired values. On the other hand, the ...

Missile defense takes place in an uncertain and dynamic environment, so multi-sensor fusion must be employed to aggregate and merge disparate data from the battlefield. However, the fusion process is hindered by the vast amount of uncertainty in operational contexts, such as imprecise measurements and varying environmental conditions. Various algorithms and fusion processes have been developed to ...

DESCRIPTION (provided by applicant): A high percentage of the ~ 470,000 children born prematurely each year in the US require intravenous feeding after birth because they do not tolerate oral feeding. This is accomplished with a total parenteral nutrition (TPN) solution, which is prepared from component solutions: small and large volume parenterals (SVPs and LVPs). Aluminum (Al) is a common conta ...

DESCRIPTION (provided by applicant): Speech is a complex motor behavior often disrupted by neurological dysfunction. Parkinson's disease (PD) is one of the main disorders disrupting speech. Recently, deep brain stimulation (DBS) has proven to be effective for motor problems in patients with PD and other movement disorders. However, the effects of DBS on speech have not been consistently positive ...

Window materials are an essential component of some advanced propulsion concepts which require high pressures, high temperatures, low energy losses, and low weights. Window materials must possess a combination of properties such as high mechanical strength, high melting point, high transparency, low density, and good resistance to the operating environment. CeraNova proposes the development of f ...

DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

The objective of this project is to evolve the RF device ontology developed in Phase I, design and implement a run time prototype system, develop a test environment and perform an evaluation of the approach developed in Phase I. Based upon the findings and success of Phase I, we propose to continue the work on the Dev2WALDO ontology, augment it with necessary concepts, design and develop a prototy ...