Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. A FAP-Activated Proteasome Inhibitor for Killing Solid Tumors

    SBC: ARISAPH PHARMACEUTICALS, INC.            Topic: 102

    DESCRIPTION provided by applicant Cancer is the second leading cause of death after heart disease in the US Chemotherapy is a mainstay of treatment after surgical removal of tumors but the balance of clinical benefit versus disabling or life threatening side effects is often uncertain Genotyping of cancers to identify mutated oncogenes has enabled an era of targeted therapy Drugs targeting ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  2. A Large Size 3D Holographic Display with PR Polymers

    SBC: BOSTON APPLIED TECHNOLOGIES, INCORPORATED            Topic: AF08T001

    In this STTR project, Boston Applied Technologies, Inc. (BATi), teaming up with Prof. Di Bartolo’s group at Boston College, aims at developing a large size (300 mm x 300 mm) updatable 3D display with photorefractive polymers for battlefield and command and control applications. The proposed 3D display system features fast response (feasible to video-rate), high diffraction efficiency, and relati ...

    STTR Phase I 2008 Department of DefenseAir Force
  3. A Real-Time, Portable Non-Invasive Monitoring System of Muscle Oxygen and pH in Trauma Patients

    SBC: Reflectance Medical Inc.            Topic: A08T037

    Trauma and severe hemorrhage remain the most frequent causes of death in the 1-44 year age group in both the civilian and military settings. Early recognition of shock and prompt institution of appropriate resuscitative measures are widely believed to improve outcome and decrease the progression to multi-system organ failure by virtue of maintaining end-organ perfusion. The physiological response ...

    STTR Phase I 2008 Department of DefenseArmy
  4. Adaptive Hierarchical Multiple Models to Control Dynamic Systems

    SBC: Scientific Systems Company Inc.            Topic: AF07T012

    Modern control theory offers mathematically rigorous and powerful solutions to many dynamic systems. Its limitations are that the classes of dynamic systems covered by the theory are limited to linear systems or certain well-structured nonlinear systems, and the adaptation of the controllers are often slow if the controller parameters are far away from their desired values. On the other hand, the ...

    STTR Phase I 2008 Department of DefenseAir Force
  5. Advanced Window Materials for High Energy Propulsion

    SBC: CERANOVA CORPORATION            Topic: AF07T009

    Window materials are an essential component of some advanced propulsion concepts which require high pressures, high temperatures, low energy losses, and low weights. Window materials must possess a combination of properties such as high mechanical strength, high melting point, high transparency, low density, and good resistance to the operating environment. CeraNova proposes the development of f ...

    STTR Phase I 2008 Department of DefenseAir Force
  6. Aptamers for Ante-mortem Diagnostics of Prion Infection

    SBC: Infoscitex Corporation            Topic: A08T035

    All forms of transmissible spongiform encephalopathy (TSE) are caused by a unique infectious agent termed “prion”, a proteinaceous pathogen lacking nucleic acid. Prions are actually a misfolded variant of the normal mammalian prion protein, PrPc. Normal disease transmission occurs when prions are ingested by a naive animal. The current test for TSE is a post mortem diagnosis looking for protea ...

    STTR Phase I 2008 Department of DefenseArmy
  7. Automated Microscopic Malaria Diagnosis

    SBC: Diagnostic Vision Corporation            Topic: A08T036

    In this project we will develop a computerized microscope based imaging system for field testing that will allow location and quantization of malarial parasites (trophozoites). The system will automatically scan a blood smear, locating the portions of the smear that are adequate for analysis and then counting the total number of red cells and the number of red cells containing parasites. The sys ...

    STTR Phase I 2008 Department of DefenseArmy
  8. Brain penetrant Hsp90 inhibitors for Alzheimer's disease

    SBC: YUMA THERAPEUTICS CORPORAITON            Topic: NIA

    DESCRIPTION provided by applicant Neurodegeneration in Alzheimerandapos s disease AD may result from deposition of A as plaques in brain tissue However less effort has been made to elucidate the role of tau containing neurofibrillary tangles NFTs in AD Accumulating evidence suggests that tau containing NFTs is an important component in the initiation and progression of AD and other neu ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  9. Coils for Human Whole Body Imaging at 7T

    SBC: LIFE SERVICES L.L.C.            Topic: NIBIB

    DESCRIPTION provided by applicant For this Phase II STTR proposal the investigators plan to develop and commercialize the radiofrequency RF coil technology to make T body MRI possible and to translate this new technology to vastly improve T clinical MRI as well In the Phase I project leading to this proposal all specific aims were accomplished to demonstrate the feasibility of safely an ...

    STTR Phase II 2014 Department of Health and Human ServicesNational Institutes of Health
  10. Commercial Methods for Production of Orientation Patterned GaAs

    SBC: Physical Sciences Inc.            Topic: AF06T010

    The Air Force desires development of a commercial production source for nonlinear optical (NLO) gallium arsenide semiconductor crystals with orientation patterning, i.e., OP-GaAs. The Phase I project has demonstrated feasibility for a fabrication method of OP-GaAs which exclusively utilizes processes anticipated to be available from commercial vendors and at Physical Sciences Inc (PSI). Molecula ...

    STTR Phase II 2008 Department of DefenseAir Force
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