Award Data

PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

DESCRIPTION (provided by applicant): This application is focused on the development of a simple and sensitive technology for the detection of CpG methylation in CpG islands of human cancer cells. CpG islands are short genomic segments in the promoter regio ns of most human genes that are enriched in the dinucleotide CpG. CpG islands are unmethylated in normal tissues but become progressively more ...

DESCRIPTION (provided by applicant): An estimated 5.4 million Americans had Alzheimer's disease in 2012 and a 50% increase in this number is expected by 2030. The majority of these patients (70%) will live at home where they receive 75% of their care frominformal caregivers, unpaid individuals such as family members, friends, and neighbors. These caregivers provide valuable services, often a ...

A critical element of our global military dominance is the overwhelming capabilities afforded by the US military space segment. Successful space operations are dependent upon accurate and actionable space situational awareness (SSA), a concept that goes beyond simple cataloging of the location and orbit of objects in space to include the ability to identify and discriminate natural and man-made ph ...

DESCRIPTION (provided by applicant): We propose to develop a compact, cost-effective Traveling Wave Tube (TWT) amplifier at 263 GHz with 50 W of peak power, 5 W of continuous wave power and 5% instantaneous bandwidth for application in Dynamic Nuclear Polarization (DNP) enhanced solid-state and solution-state NMR and Electron Paramagnetic Resonance (EPR) spectroscopy. With DNP, the inherently smal ...

ABSTRACT: Research Objectives: 1) Quantify the size, weight, power consumption and cost of flight units of the Space-based InfraRed Imaging Interferometer (SIRII) sensor. 2) Quantify the fundamental advantages of the interferometric approach in comparison to conventional sensor design. 3) Quantify the impact of disadvantages of the interferometer. 4) Establish the steps required to mature the des ...

DESCRIPTION (provided by applicant): A Compact Soft X-Ray Microbeam Facility for Small Laboratories: Radiation due natural and manmade sources is ubiquitous; research into its effects -- both harmful and beneficial -- is a major component of the mission of the NIH and related health agencies. Radiobiological microbeams are facilities able to deliver precise radiation insults to individual cells (o ...

This Small Business Innovation Research Phase I project develops a coupled computational aeroelasticity and thermal response analysis tool that can be used to analyze and design ballistic reentry vehicles and Trajectory Shaping Vehicles (TSV). In Phase I, a well validated thermal response analysis module will be integrated into a well validated computational aeroelasticity code. In Phase II, a gas ...

DESCRIPTION (provided by applicant): Retransfusion of a patient's shed blood during cardiopulmonary bypass is attractive since it reduces the need for allogeneic transfusion, minimizes cost, and decreases transfusion related morbidity. Heterologous transfusions are linked to increased long term mortality after cardiac surgery. However, brain damage after cardiac surgery with retransfusion of ...