Award Data

PROJECT SUMMARY Cardiac valve repair or replacement is indicated when progression of degenerative disease or bacterial infection of the native valve results in valvular dysfunction, thereby impacting cardiac output. Both procedures require the use of a woven or knitted polyester material with an internal reinforcement (Teflon, silicone or metal) to either stabilize the native valve (annuloplasty r ...

DESCRIPTION (provided by applicant): Over 60,000 prosthetic grafts, which are comprised of either polyethylene terephthalate (polyester) or expanded polytetrafluoroethylene (ePTFE), are implanted in the United States each year. Medium (6-8mm) and small (l t5mm) internal diameter (I.D.) prosthetic arterial grafts continue to have unacceptably high failure rates when used in the clinical setting. T ...

7. Project Summary/Abstract We propose to develop a Biological Small-angle X-ray Scattering (BioSAXS) station for the Compact Light Source, a powerful new generation of X-ray sources, which will enable biologists and biochemists to pursue state-of-the-artresearch in macromolecular structure studies in their own laboratories. The frontier of structural biology is the determination of large macromol ...

DESCRIPTION provided by applicant The growing populations of the elderly and those with type II diabetes are at high risk for developing chronic wounds that are slow to heal Effective therapeutics to promote wound healing could significantly improve the lives of these people Normal wound healing involves a coordinated cascade of events that are stimulated in part by the hypoxia that results f ...

DESCRIPTION (provided by applicant): Objective: This Phase 1 SBIR proposes to optimize the interface and interaction of a digital translation of Evidence Based Falls Prevention programs for use across the continuum of care and community living that affordseasy adoption, adherence and monitoring of falls prevention exercises for all stakeholders including those with limited technical experience. Pu ...

ABSTRACT: For certain weapons systems, lethality is directly correlated to the orientation of the weapon with respect to the target at impact, also known as the angle of incidence (AOI). Accurately measuring AOI is of the utmost importance in developing and advancing state-of-the-art precision weapon systems. Currently, there is no commercially available sensor system for measuring AOI to the pre ...

DESCRIPTION (provided by applicant): An estimated 5.4 million Americans had Alzheimer's disease in 2012 and a 50% increase in this number is expected by 2030. The majority of these patients (70%) will live at home where they receive 75% of their care frominformal caregivers, unpaid individuals such as family members, friends, and neighbors. These caregivers provide valuable services, often a ...

DESCRIPTION (provided by applicant): The goal of this research is to develop an economical, safe, effective therapy to reverse the activity of the catalytic component, LF, of the Bacillus anthracis toxin (lethal toxin), within the cytoplasm of the intoxicated cell. Success in achieving this goal will lead to better outcomes than currently seen with antibiotics or antitoxins like raxibacumab or PB ...

DESCRIPTION (provided by applicant): Although the U.S. teen pregnancy rate has declined significantly over the last decade, it remains higher than that of many other industrialized countries and U.S. teens remain at high risk of acquiring HIV and other STI s. A number of behavioral interventions for teens have shown efficacy in reducing unsafe sexual practices that lead to pregnancy and STIs/HIV. ...

A critical element of our global military dominance is the overwhelming capabilities afforded by the US military space segment. Successful space operations are dependent upon accurate and actionable space situational awareness (SSA), a concept that goes beyond simple cataloging of the location and orbit of objects in space to include the ability to identify and discriminate natural and man-made ph ...