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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Harvesting specific plant metabolites from hairy root cultures using magnetized n

    SBC: NAPROGENIX, INC.            Topic: NCCIH

    DESCRIPTION: Plants produce a wide variety of valuable bioactive metabolites, but these are commonly present in low concentrations in the wild-type plant. This makes the separation and purification of these compounds complicated and expensive. The applicant company, Naprogenix Inc, has developed a technology for increasing the yields of specific bioactive metabolites in mutant plant cell cultures ...

    STTR Phase I 2014 Department of Health and Human Services
  2. Mitochondrial Uncoupling as a Therapeutic Target in Obesity

    SBC: Nano-Mite Technologies, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Obesity is recognized as a national and global epidemic, as approximately 65% of adults in the United States are classified as overweight or obese as defined by body mass index (BMI). In fact, in the year 2000, the human race reached a historical landmark, when for the first time in history the number of adults with excess weight surpassed the number of those w ...

    STTR Phase I 2014 Department of Health and Human Services
  3. Hand Rehabilitation using Variable Assistance through Force and EMG Feedback

    SBC: KORONIS BIOMEDICAL TECHNOLOGIES CORP.            Topic: NIA

    DESCRIPTION (provided by applicant): This project proposes to develop and evaluate a hand rehabilitation system for chronic hemiparetic stroke survivors that have lost their ability to full control their hand. Stroke is the leading cause of adult disability, and is the third leading cause of death in the United States. Stroke survivors often face a significant loss of functional motor control in ...

    STTR Phase I 2014 Department of Health and Human Services
  4. Exosomal drug formulations

    SBC: 3P BIOTECHNOLOGIES, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): More people in the U.S. (160,340 per year) die of lung cancer than of prostate, breast, and colon cancer combined. The most common type of lung cancer, non-small-cell lung cancer (NSCLC), accounts for 75% of all lung cancers. Regrettably, 85% of all patients diagnosed with NSCLC eventually die of the disease within 5 years, due to micro-metastasis and relapse. ...

    STTR Phase I 2014 Department of Health and Human Services
  5. Prevention of erectile dysfunction following prostate cancer radiotherapy

    SBC: Humanetics Corporation            Topic: NCI

    DESCRIPTION (provided by applicant): The aim of this proposal is to evaluate BIO 300 as an effective therapy to prevent and/or mitigate the erectile dysfunction (ED) that is commonly observed following radiotherapy (RT) for prostate cancer. Prostate cancer is the most common cancer among men in the United States. Approximately half of prostate cancer patients will undergo RT as a part of thei ...

    STTR Phase I 2014 Department of Health and Human Services
  6. Small Molecule Inhibitors of HIV1 Nef Virulence Factor for Treatment of HIV_AIDS

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NIGMS

    DESCRIPTION: While HIV/AIDS can be managed with antiretroviral drugs that block viral replication, these agents do not clear the virus and require life-long drug administration with associated risks of cumulative toxicity and drug resistance. Recently, wediscovered a completely new class of compounds that interfere with the HIV-1 virulence factor, Nef. This viral protein is critical to HIV-1 repli ...

    STTR Phase I 2014 Department of Health and Human Services
  7. Small Molecule Antagonists of PF4 for the Treatment and Prevention of HIT

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NHLBI

    We have discovered the first-ever inhibitors of PF4, a platelet protein central to the pathophysiology of heparin induced thrombocytopenia (HIT). Heparin is a naturally-occurring anticoagulant that prevents the formation of clots and extension of existingclots within the vasculature, and major medical applications of heparin include dialysis, cardiac catheterization, and cardiopulmonary bypass sur ...

    STTR Phase I 2014 Department of Health and Human Services
  8. Location Initiated Individualized Texts for African American Adolescent Health

    SBC: MEI Research, Ltd            Topic: NIMHD

    DESCRIPTION (provided by applicant): Obesity in the U.S. has disproportionately affected African American (AA) adolescents who have almost twice the prevalence of obesity than their Caucasian peers. This is due in part to greater exposure to, and higher consumption of, 'fast' and calorie dense foods among minority vs. majority populations. Finding effective ways to address dietary habits ...

    STTR Phase I 2014 Department of Health and Human Services
  9. A Wireless Device to Monitor and Track Fluid Consumption in At-Risk Older Adults

    SBC: Smart Activity of Daily Living, LLC            Topic: NINR

    DESCRIPTION (provided by applicant): The long term goal of the proposed project by Smart Activities of Daily Living, LLC (Smart ADLs) is to develop a device (the Smart Cup) that will improve the health of older adults by managing nutrition using smart health technology. Malnutrition (under nutrition) is a common geriatric syndrome found in older adults across the care continuum. Older adults accou ...

    STTR Phase I 2014 Department of Health and Human Services
  10. Transdermal Naltrexone for Opiate Addiction and Alcoholism

    SBC: ALLTRANZ, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction. Naltrexone (NTX), an opioid antagonist, is currently used in oral tablet form to help maintain opio ...

    STTR Phase II 2014 Department of Health and Human Services

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