Award Data

DESCRIPTION (provided by applicant): Current human rabies virus (RV) vaccines are effective if administered in an appropriate and timely manner and therefore, RV infection is a vaccine-preventable disease. However, immunization protocols are complex, requiring multiple doses over a period of weeks and in some cases months. High costs and the lack of compliance associated with current vaccines, and ...

DESCRIPTION: Renal transplantation is the preferred therapeutic approach for end organ failure. However, the chronic use of immunosuppressive agents is critical to prevent rejection. The drugs are costly ( 15,000-25,000/year) and have significant toxicities including opportunistic infection, an increased rate of malignancy, nephrotoxicity, and other end organ damage. The induction of donor-specifi ...

There is a well-understood need for a small bioinformatics based wearable critical care monitor allowing for the remote monitoring and triage of wounded warfighters. Our Phase I research demonstrated that by augmenting a commercial wearable body monitoring device (BodyMedia"s SenseWear Armband) with ECG and sophisticated signal processing including the wavelet transform invented at Virginia Commo ...

ABSTRACT: We are experiencing grand challenges to ensure that cyberspace resources and services can effectively tolerate epidemic-style cybperattacks, and manage automatically its resources and services. Currently, there are no effective commercial technologies to secure and protect cyberspace resources and services; they are mainly labor intensive (e.g., patch update), signature based, and not f ...

ABSTRACT: Our Phase II program concentrates on extending, rectifying, and validating the ETM engineering transition model for 3D flows. ETM solves PDE"s for both transition onset and intermittency and has full 3D capabilities, shown to generate swept onset curves and variable transitional lengths downstream of the onset curve. It is incorporated into Navier-Stokes codes in a manner akin to the i ...

DESCRIPTION (provided by applicant): Under the acronym Survey and Test Platform for use in Underserved Populations, Phase II (STeP- UP2), Advanced Medical Electronics Corp, in collaboration with the Johns Hopkins University School of Medicine and several secondary partners, proposes to expand the prototype hardware/software platform called STeP-UP created in the first phase of this STTR project. W ...

DESCRIPTION (provided by applicant): There is a significant unmet medical need to provide additional pharmacologic treatments for treatment and prevention of opioid overdose. This Fast Track STTR project proposes to apply drug delivery technologies to develop a novel use for a nasally delivered pharmaceutical - naloxone (NLX) hydrochloride - for the emergency treatment of opioid overdose by emerge ...

We propose a rapid mapping and 3-D visualization system especially suited for inside buildings, tunnels, urban canyons, and other environments where GPS may be poor or not available. The system--which was fully demonstrated in our Phase I effort-- includes mobile Sensor Nodes that wirelessly supply compressed 3D range data and color imagery to a central Fusion Node. The Fusion Node runs 3D recon ...

ABSTRACT: The Phase II technical objectives follow directly from the Phase I effort, where all tasks necessary for RF photonic receiver fabrication were demonstrated. The Phase II effort will pursue two major objectives: 1) further development of SEO100 EO polymer based chips, packaged devices and arrays in collaboration with University of Dayton (antenna designs), taking advantage of multiphoto ...

This project address the fabrication of solar blind detectors from the MgZnO material system. Both MBE and MOCVD material growth techniques will be used for deposition of the required material layers. Simulation software we be used to aid in the design of the photodetector structure. Devices will be fabricated from the grown structures and their electrical and optical characteristics determined.