Award Data

A parallel random number generation suite that generates, dynamically, millions of parallel pseduorandom number streams suitable for consumption by high performance computing (HPC) applications on various platforms will be implemented, tested, and provided to Government, academic and private HPC users for their evaluation and use. The software will be tuned for scalability, repeatability and effic ...

ABSTRACT: The overall technical objectives of the Phase II efforts are to develop, implement, and validate a computationally efficient and accurate buffet load predictive capability in ZONA's Stick-To-Stress Dynamic Flight Simulation (STS-DFS). This capability will allow a continuous simulation of the aircraft in STS-DFS for smoothly varying angle of attack and speed providing aircraft attit ...

ABSTRACT: The objective of this project is to develop sophisticated, graphical user interface driven software tools built on fully microscopic physics to design, guide and provide feedback on growth, fabrication and evaluation of semiconductor structures that provide optical gain in the critical 2.4-4 micron window. The mid-IR laser software design development has several potential applications t ...

ABSTRACT: The chalcogenide based ion-conducting memristor has been shown to be an effective element as the core of a simple neuromorphic computing circuit. The response of the computing circuit is the result of weighted external stimuli, the current state of the device, and the history of exposure by the device to the stimuli. A highly specialized version of the device, as developed by the Advanc ...

A vaccine to protect against diseases resulting from infection with Streptococcus pyogenes is under development. This vaccine utilizes a recombinant fusion protein (SpeAB) comprising of genetically detoxified SpeA, a secreted toxin, and SpeB, a surface bound and secreted cysteine protease. During phase I investigations a lead vaccine formulation was determined by optimization of critical paramet ...

DESCRIPTION: The following proposal is a follow-on Phase 2 b application from our initial proposal (1-R42 DA 030001). U.S. drug overdose deaths, mostly commonly from opioids, now exceed deaths from automobile accidents. There is a significant unmet medical need to provide additional pharmacologic options for treatment of opioid overdose. Emergency medical service personnel would prefer a non- inj ...

DESCRIPTION (provided by applicant): Molecular interactions form the foundation of biology and chemistry. They are central to life itself and determine catalytic activity, cellular function, and therapeutic efficacy. The vast majority of diagnostic procedures depend on some type of specific molecular interaction. Therefore, the ability to perform pure liquid-phase molecular binding analysis at hi ...

DESCRIPTION (provided by applicant): Our proposal describes an elegant device called the Bumps that quantifies touch sensation on the fingers at low micron levels. The objectives are to diagnose peripheral neuropathy near its onset, when the possibility for reversal is highest, and to monitor either progression or reversal of neuropathy during treatment. Target neuropathies are those related to ch ...

ABSTRACT: The Tai-Yang Research Company (TYRC) of Tallahassee, FL in collaboration with Dr. Justin Schwartz of the North Carolina State University (NCSU) in Raleigh, NC propose in this Phase 2 effort to develop the critical technologies necessary for the implementation and operation of an airborne high temperature superconductor (HTS) superconducting magnetic energy storage (SMES) device with par ...

We propose a rapid mapping and 3-D visualization system especially suited for inside buildings, tunnels, urban canyons, and other environments where GPS may be poor or not available. The system--which was fully demonstrated in our Phase I effort-- includes mobile Sensor Nodes that wirelessly supply compressed 3D range data and color imagery to a central Fusion Node. The Fusion Node runs 3D recon ...