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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SURFACE MODIFICATION FOR IMPROVED PERCUTANEOUS CATHETERS

    SBC: SURMODICS, INC.            Topic: N/A

    MANY LIFE-SAVING PROCEDURES NOW REQUIRE THE INSERTION OF LONG-DWELLING PERCUTANEOUS CATHETERS (I.E., SEVERAL TYPES OFVASCULAR CATHETERS AND PERITONEAL DIALYSIS CATHETERS). IDEALLY, THESE CATHETERS SHOULD BE BOTH COMPATIBLE WITH THE TISSUES THEY ENCOUNTER AND PROVIDE AN EFFECTIVE BARRIER AT THE EPIDERMIS TO PREVENT MICROBIAL INVASION. CURRENTLY, NO CATHETERS PROVIDE AN ADEQUATE SEAL AT THE SKIN SUR ...

    SBIR Phase II 1990 Department of Health and Human Services
  2. ENZYME IMMOBILIZATION FOR REMOVAL OF TOXIC METABOLITES

    SBC: SURMODICS, INC.            Topic: N/A

    ENZYME DEFICIENCIES ASSOCIATED WITH INBORN METABOLIC DEFECTSARE USUALLY FATAL WITHIN THE FIRST FEW YEARS OF LIFE. TREATMENTS SUCH AS DIET MANIPULATION, GENE REPLACEMENT THERAPY, CHEMOTHERAPY, TRANSFUSIONS, TRANSPLANTATIONS, AND PERITONEAL DIALYSIS HAVE PRODUCED MARGINAL IMPROVEMENTS IN THESE PATIENTS. ENZYME REPLACEMENT THERAPY IS AN APPEALING ALTERNATIVE OR ADJUNCT TO THESE TREATMENTS. HOWEVER, D ...

    SBIR Phase II 1990 Department of Health and Human Services
  3. IN VIVO TESTING OF AN IMPROVED VASCULAR PROSTHESIS

    SBC: SURMODICS, INC.            Topic: N/A

    NO ADEQUATE SMALL DIAMETER VASCULAR PROSTHESES ARE NOW COMMERCIALLY AVAILABLE, WITH THE MAJOR REASONS FOR LOSS OF PATENCY BEING THROMBUS FORMATION AND NEOINTIMAL FIBROUS HYPERPLASIA. ALSO, GRAFTS ARE OFTEN THE SITE OF CHRONIC INFECTIONS. THIS PROPOSED FEASIBILITY STUDY EXPECTS TO IMPROVE THE BIOCOMPATIBILITY OF COMMERCIALLY AVAILABLE VASCULAR IMPLANT POLYMERS BY SELECTIVELY IMMOBILIZING EXTRACELLU ...

    SBIR Phase II 1990 Department of Health and Human Services
  4. SURFACE MODIFICATION FOR INFECTION-RESISTANT BIOMATERIALS

    SBC: SURMODICS, INC.            Topic: N/A

    INFECTIONS ARE THE MOST SERIOUS COMPLICATION OF MEDICAL DEVICES. A HIGH INCIDENCE OF INFECTION IS ASSOCIATED WITH ALL DEVICES, INCLUDING CONTACT LENSES, CATHETERS, DIALYSIS MATERIALS, AND CARDIOVASCULAR IMPLANTS. INFECTIONS ARE TREATED AS THEY OCCUR, BUT PREVENTION IS THE MOST PROMISING APPROACH TO DECREASING THESE PROBLEMS. ONE LIKELY METHOD FOR REDUCING DEVICE-RELATED INFECTIONS IS TO BOND A COA ...

    SBIR Phase I 1990 Department of Health and Human Services
  5. ANTIBODY EXTRACTION FOR DETECTION OF LIPOPHILIC ANALYTES

    SBC: SURMODICS, INC.            Topic: N/A

    THIS PROJECT WILL DEVELOP A METHOD FOR USE IN NONLABORATORY ENZYME IMMUNOASSAY DETECTION KITS THAT WILL USE MODIFIED ANTIBODY FOR EXTRACTING HYDROPHOBIC CHEMICALS (ANALYTES) FROM A LIPID OR OIL PHASE IN A SAMPLE WITHOUT THE USE OF FLAMMABLE OR TOXIC SOLVENTS. THE CONCEPT IS TO COVALENTLY COUPLE A POLYMERIC COATING TO ANTIBODY TO RENDER IT CAPABLE OF BINDING ANALYTES (HAPTENS) THAT ARE RELATIVELY I ...

    SBIR Phase I 1990 Department of Health and Human Services
  6. STABILIZATION OF ANTIBODIES FOR ELISA ASSAYS

    SBC: SURMODICS, INC.            Topic: N/A

    THIS RESEARCH WILL DEVELOP METHODS TO SIMULTANEOUSLY IMMOBILIZE AND COVALENTLY CROSS-LINK ANTIBODIES OR ANTIGENS ONTO POLYSTYRENE TUBES OR MICROTITER PLATES. THE COVALENTLYIMMOBILIZED ANTIBODIES WILL BE STABILIZED BY MULTIPOINT COUPLING TO HYDROPHILIC POLYMERS ON THE POLYSTYRENE SURFACE. THUS, THE ANTIBODIES WILL BE PROTECTED FROM THE HYDROPHOBIC POLYSTYRENE AND CROSS-LINKED TO ACHIEVE STABILIZATI ...

    SBIR Phase I 1990 Department of Health and Human Services
  7. SURFACE MODIFICATION TO IMPROVE URINARY CATHETER FUNCTION

    SBC: SURMODICS, INC.            Topic: N/A

    CURRENTLY USED URINARY CATHETERS PRODUCE PAIN UPON INSERTION, INJURE ADJACENT TISSUE, AND CAUSE HIGH RATES OF BACTERIAL INFECTIONS. THESE ADVERSE EFFECTS ARE MEDIATED BYUNDESIRABLE SURFACE PROPERTIES OF THE CATHETER POLYMERS. THIS PHASE I PROJECT WILL UTILIZE PHOTOIMMOBILIZATION TECHNOLOGY TO COVALENTLY IMMOBILIZE REAGENTS EXPECTED TO BOTH IMPROVE THE LUBRICITY OF CATHETER SURFACES AND DECREASEBAC ...

    SBIR Phase I 1990 Department of Health and Human Services
  8. IMMOBILIZATION OF BIOMOLECULES

    SBC: SURMODICS, INC.            Topic: N/A

    IMMOBILIZATION OF BIOMOLECULES RESULTS IN GREAT LOSSES OF SPECIFIC ACTIVITIES OF THE IMMOBILIZED MOIETIES. THE USE OF HYDROPHILIC SPACERS BETWEEN THE BIOMOLECULES AND THE MATRIX RESULTS IN IMPROVED ACTIVITIES. HOWEVER, FACILE INTRODUCTION OF SUCH SPACERS ONTO MANY INSOLUBLE SUPPORTS ISDIFFICULT WITHOUT CAUSING DAMAGE TO THE SUPPORT OR THE USE OF SOPHISTICATED CHEMISTRY. DURING PHASE I, IT WAS DEMO ...

    SBIR Phase II 1990 Department of Health and Human Services
  9. PHOTOCHEMICALLY BONDED SLIPPERY SURFACES FOR MEDICAL DEVICE MATERIALS

    SBC: SURMODICS, INC.            Topic: N/A

    THE GOAL OF THIS PROJECT IS TO DEMONSTRATE THE BENEFIT OF UTILIZING PHOTOCHEMISTRY AS A GENERIC METHOD FOR INTRODUCINGBONDED, SLIPPERY COATINGS TO MEDICAL DEVICES. IT IS ANTICIPATED THAT THIS APPROACH WILL BE SUPERIOR TO CURRENT METHODS. THIS TECHNOLOGY WILL BE USED TO PREPARE SURFACES THAT ARE "WET-STATE LUBRICIOUS" (I.E., REQUIRING HYDRATION TO BE SLIPPERY) AND SURFACES THAT ARE "DRY-STATE LUBRI ...

    SBIR Phase I 1990 Department of Health and Human Services
  10. SURFACE MODIFICATION OF BIOMATERIALS FOR THROMBOSIS PREVENTION

    SBC: SURMODICS, INC.            Topic: N/A

    N/A

    SBIR Phase I 1990 Department of Health and Human Services

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