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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Clinical Human Cell Production System for Broad Use

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

    SBIR Phase I 2003 Department of Health and Human Services
  2. Enhanced Tumor Antigen Priming of Dendritic Cell Vaccine

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

    SBIR Phase I 2003 Department of Health and Human Services
  3. Automated Perfused Culture Process for Adult Stem Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

    SBIR Phase I 2003 Department of Health and Human Services
  4. Clinical-scale Production of Osteoprogenitor Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

    SBIR Phase I 2003 Department of Health and Human Services
  5. Automated Large-Scale Production of Endothelial Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...

    SBIR Phase I 2003 Department of Health and Human Services
  6. Heterologous Expression of Marine Natural Products

    SBC: ACERA BIOSCIENCES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Marine natural products are diverse in chemical structure and have great biological activities, especially anticancer activities. However, developing these compounds into clinical drugs has been hindered by their limited supply. Acera Biosciences, Inc. has developed a strategy to produce these compounds in fermentation. The proposed research project focuses ...

    SBIR Phase I 2003 Department of Health and Human Services
  7. Wireless Home Patient-Management Internet Appliances

    SBC: ADVANCED MEDICAL ELECTRONICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Advanced Medical Electronics Corporation (AME) proposes to develop a self-discovering wireless connectivity network for medical devices used in the home. Devices utilizing this network will automatically communicate with a home patient-management Internet appliance using a self-discovering wireless link. A self-discovering wireless network is a communication ...

    SBIR Phase II 2003 Department of Health and Human Services
  8. Wireless Home Patient-Management Internet Appliances

    SBC: ADVANCED MEDICAL ELECTRONICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Advanced Medical Electronics Corporation (AME) proposes to develop a self-discovering wireless connectivity network for medical devices used in the home. Devices utilizing this network will automatically communicate with a home patient-management Internet appliance using a self-discovering wireless link. A self-discovering wireless network is a communication ...

    SBIR Phase I 2003 Department of Health and Human Services
  9. Development of a Flexible Infrared Imaging Endoscope

    SBC: ADVANCED MEDICAL ELECTRONICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) proposes to develop a flexible infrared microbolometer based endoscope for use during surgical heat treatments to accurately measure tissue temperatures. The primary phase II goal is to create the smallest far-infrared camera ever developed to provide real-time spatially accurate two-dimensional surface temperature measurem ...

    SBIR Phase I 2003 Department of Health and Human Services
  10. Polysomnograph on a Chip

    SBC: ADVANCED MEDICAL ELECTRONICS CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): Advanced Medical Electronics (AME) proposes to develop a full-featured polysomnograph system on an integrated circuit (IC). Advances in System-On-a-Chip (SOC) design tools and foundry processes make the proposed system possible within a relatively low cost budget. The phase I program established the feasibility of developing an integrated circuit polysomnograph ...

    SBIR Phase I 2003 Department of Health and Human Services

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