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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 5490 results
  1. Milestone Mall

    SBC: 21ST CENTURY SYSTEMS, INC.            Topic: N/A

    There are major changes in today's business methods. Expensive and time consuming travel for gathering project personnel together will be replaced, in part, by network-centric technology. Management directives of large corporations are increasinglystipulating the use of a collaborative workspace environment for their organizations that are non-collocated. In the defense sector, time-to-market of ...

    SBIR Phase I 2003 Department of DefenseAir Force
  2. Eigen-Similarity Integral (ESI)- A New Concept for Invariant Image Similarity Detection

    SBC: 21ST CENTURY SYSTEMS, INC.            Topic: N/A

    Most of today's precision guided weapons use Global Positioning System (GPS) signals to gain improved accuracy. But, as Operation Iraqi Freedom recently showed, foreign militaries have equipment to locally jam GPS signals. Another effective method ofautonomous navigation is necessary to ensure mission success. Similar to rudimentary terrain recognition used in early cruise missiles, the matching o ...

    STTR Phase I 2003 Department of DefenseAir Force
  3. High-Energy Laser Coatings for Large, Lightweight, and Compliant Deployable Space Optics

    SBC: ALAMEDA APPLIED SCIENCES CORPORATION            Topic: N/A

    Alameda Applied Sciences Corporation proposes to use its Filtered Cathodic Arc Plasma Deposition (FCAPD) process to apply reflective high-energy laser coatings to complaint polyamide substrates for space-based mirrors. FCAPD coatings have better adhesionand are denser and more stable than coatings deposited using other methods, such as, sputtering or evaporation. In addition, the internal stress o ...

    SBIR Phase I 2003 Department of DefenseAir Force
  4. Clinical Human Cell Production System for Broad Use

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): As a result of growing evidence of their therapeutic potential in cancer, infectious diseases, and tissue repair, there is an enormous increase in the research and discovery of cell-based medical treatments that require cultured cells. A large unmet need exists for a cost-effective system that will facilitate the development of clinical cell production capabil ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  5. Enhanced Tumor Antigen Priming of Dendritic Cell Vaccine

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by the applicant): Dendritic cells have been shown to initiate, regulate, and direct cytolytic T-cell-mediated immune responses against tumor antigens in human patients. Recent clincal trials have demonstrated induction of clinically significant immune responses against malignant diseases using DCs primed ex vivo with autologous tumor antigens including tumor cell lysates. E ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  6. Automated Perfused Culture Process for Adult Stem Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Adherent mesenchymal cell populations derived from bone marrow (BM) have the capability of differentiating into multiple cell lineages in vitro and in vivo. The potential use of these populations, referred to as marrow stromal cells (MSC), in clinical applications to treat nonhematopoietic disorders is being intensely investigated. Ex vivo expansion is being us ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  7. Clinical-scale Production of Osteoprogenitor Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Due to morbidity and limited amounts of material, alternatives to autologous grafts for bone repair are desirable. Mixtures of marrow stromal cells (MSC) and carrier matrices are known to augment bone repair. Increasing the number of MSC through ex vivo expansion may significantly increase the amount and rate of new bone formation. In this proposal, the abilit ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  8. Automated Large-Scale Production of Endothelial Cells

    SBC: Aastrom Biosciences, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Treatment of ischemia by administration of bone marrow (BM)-derived endothelial progenitor cells (EPC) or ex vivo expanded EPC populations has been shown to enhance vascular regeneration in animal models and in clinical trials. For cell therapy to be practical in a clinical setting, simple, efficient, GMP compliant methods for cell production are needed. Aastro ...

    SBIR Phase I 2003 Department of Health and Human ServicesNational Institutes of Health
  9. Effects-Based Counter Terrorism Operations

    SBC: DEUMBRA, INC.            Topic: N/A

    The objective of this Phase I effort is to apply concepts in social network analysis to support effects-based plan development at the strategic level for counter-terrorist operations. We will exploit Dr. John Lemmer's CAT (Causal Analysis Tool) tosupport plan assessment. Mr John Beyerle, an EBO expert and Mr. Craig Robinson, a 20 year decorated DIA senior counter-intelligence analyst shall serv ...

    SBIR Phase I 2003 Department of DefenseAir Force
  10. Advanced Information Understanding Algorithms to Detect Counter-Terrorist Activity in Support of Total Force Protection

    SBC: DEUMBRA, INC.            Topic: N/A

    In this proposal 21st Century Technologies will (1) conceptually combine multiple social network patterns to provide greater visibility and a deeper understanding of anomalous and possibly terrorist behaviors to support force protection (2) implementthese combined constructs into an social network pattern library usable for military security analysts and (3) integrate the library into TMODS. ...

    SBIR Phase I 2003 Department of DefenseAir Force
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