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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. AlphaBear

    SBC: Spry Fox LLC            Topic: 1

    In prior research and development, the team developed AlphaBear, a mobile gaming app where students are challenged to spell words which are then used to create humorous sentences. This project will develop and test a prototype for use specifically by English Learners. The prototype will formatively assess students' vocabulary, adjust gameplay to the skill levels of individual students, and provide ...

    SBIR Phase I 2016 Department of Education
  2. Development of novel isoflavone drugs as broad spectrum antivirals

    SBC: KINETA, INC.            Topic: R

    DESCRIPTION provided by applicant Kineta has discovered a novel class of broad spectrum small molecule antivirals that function through a host directed mechanism These compounds have demonstrated an innovative mechanism of action and target several high priority pathogens that are commercially valuable The lead chromenone based candidates have potency in the nM range inhibit multiple viruses ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Novel therapeutic agent to prevent hearing loss during aminoglycoside therapy

    SBC: Oricula Therapeutics LLC            Topic: NIAID

    DESCRIPTION provided by applicant Aminoglycoside antibiotics AGs are important for the treatment of a variety of serious infectious diseases including septicemia complicated intra abdominal infections complicated urinary tract infections and nosocomial respiratory tract infections AGs are the mainstay of treating Pseudomonas infection in patients with cystic fibrosis and one of the best c ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Refinement of an Autocidal Gravid Ovitrap for mass manufacturing

    SBC: Springstar, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Lethal ovitraps are a modification of a common mosquito population monitoring technology adult females are enticed to a water container to lay their eggs and are exposed to a lethal dose of pesticide The Autocidal Gravid Ovitrap AGO improves this technology in several ways It has been modified to make it more attractive to gravid Aedes aegypti The killing ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Semiconducting Polymer Dots for Multiplexed Assays

    SBC: LAMPROGEN INC            Topic: 400

    DESCRIPTION provided by applicant Fluorescence based methods play an essential role in modern cell biology and biomedical research Further development of these techniques has been hindered by the lack of suitable fluorescent probes To overcome this challenge various fluorescent nanoparticles have been developed Among those semiconducting polymer dots Pdots exhibit superior properties suc ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. An Active Hemostatic Clamping Device for Bloodless Surgery and Trauma

    SBC: NOVUSON SURGICAL, INC.            Topic: 300

    DESCRIPTION provided by applicant Bleeding complications occurred in approximately of surgical procedures In trauma to of deaths are related to uncontrolled bleeding Blood transfusions and reoperations are used to mitigate bleeding and avert death however these procedures can be costly and are associated with complications Blood transfusion can lead to nosocomial infection im ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Tool for non invasive delivery of central nervous system drug candidates

    SBC: IMPEL NEUROPHARMA, INC.            Topic: 101

    DESCRIPTION provided by applicant Impel NeuroPharma is developing a nose to brain drug delivery device to enable drugs to bypass the blood brain barrier BBB in humans This Phase II SBIR aims to develop robust non custom and affordable devices for use in preclinical studies that makes the technology more accessible to researchers everywhere During this project Impel will be assisted by Dr ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Optimization of a novel cancer immunotherapeutic antibody for human use

    SBC: CANCURE LLC            Topic: 102

    ABSTRACT The goal of this application is to evaluate the cancer therapeutic feasibility of CanCureandapos s humanized first in class immunostimulatory monoclonal antibody mAb huB G the Product also names CuraB During cancer development in response to oncogenic insult or stress almost ALL human cancer cells are induced to express a SURFACE molecule MIC MHC I chain related Molecule wh ...

    STTR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Development of Monoclonal Antibodies to Treat Pancreatic Cancer

    SBC: COARE BIOTECHNOLOGY, INC.            Topic: NCI

    Abstract Pancreatic ductal adenocarcinoma PDAC is a devastating cancer with an extremely low year survival rate even for those who are diagnosed early Novel research suggests that this may be the result of metastatic dissemination preceding or concurrent to the development of the primary tumor Epithelial mesenchymal transition EMT is one of the key pathways in pancreatic cancer invasion ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Phase II clinical evaluation of Omnitram in neuropathic pain

    SBC: Syntrix Biosystems, Inc.            Topic: R44

    DESCRIPTION provided by applicant Neuropathic pain is caused by damage to the peripheral nerves as occurs in diabetic neuropathy Neuropathic pain is difficult to treat and many patients have pain that is refractory to existing treatments Omnitram is a novel mixed mechanism analgesic developed by Syntrix that consists of the and enantiomers of O desmethyltramadol The enantiomer ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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