Award Data

DESCRIPTION (provided by applicant): The long-term product goal of this project is a small molecule therapeutic to treat rheumatoid arthritis (RA), which acts by reducing the inflammatory response triggered by the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF). Since MIF is an upstream regulator of the inflammatory cascade, small molecule therapeutics targeting MIF activity ...

Current energy storage devices have energy densities that are barely sufficient for low cost electric-vehicles and rely on lithium ion batteries that use flammable, unsafe, liquid electrolytes. However, in order to replace liquid electrolyes in lithium batteries for hybrid electric power train systems, solid polymer electrolytes, which have the advantages of safety and flexibility, must attain con ...

The quest for deepened understanding of the origin of the universe requires continued search for elementary particles, for which high-energy accelerators are necessary tools. Reducing the size, complexity, and cost for future accelerators is essential if they are ever to be built. New technologies that can underlie future accelerators be they for basic science or for applications are needed to m ...

The quest for deepened understanding of the origin of the universe requires continued search for elementary particles, for which high-energy accelerators are necessary tools. Reducing the size, complexity, and cost for future accelerators is essential if they are ever to be built. New technologies that can underlie future accelerators, be they for basic science or for applications, are needed to ...

Efficient, cost effective production of hydrogen from non-carbon based sources is a key barrier to widespread implementation of fuel cells for transportation and stationary power. Ion exchange membrane-based electrolysis is a promising technology for clean generation of pure hydrogen, but significant advances are required in order to provide cost-competitive hydrogen source for energy markets. Com ...

DESCRIPTION (provided by applicant): All forms of diabetes are characterized by the death of insulin producing cells. In Type 1 diabetes (T1D), this leads to the reliance on exogenous insulin for survival. In addition, there is cell loss in T2D and inindividuals who lose islet or pancreas allografts. New therapies have been developed that can modulate the course of T1D but the effective appli ...

DESCRIPTION (provided by applicant): We propose to develop a software package to automatically evaluate a subject's beta amyloid PET scan (using either C11-PIB, F18-florbetaben, or F18-florbetapir, F18-flutemetamol) by normalizing the subject's scan, masking away non-gray matter tissue (without relying on co-registered MRI scans), placing standardized ROIs onto the transverse slices, and ...

Efficient, cost effective production of hydrogen from non-carbon based sources is a key barrier to widespread implementation of fuel cells for transportation and stationary power. Electrolysis is a promising technology for clean generation of pure hydrogen from water, but significant advances are required in order to provide a cost-competitive hydrogen source for energy markets. Commercial proton ...

DESCRIPTION (provided by applicant): Lyme disease, due to infection with the Ixodes tick-transmitted spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States, with over 38,000 confirmed and probable cases reported to the CDC in 2009. Spirochetes first establish infection in the skin and then disseminate to internal organs such as the heart, the joints, and the ...

DESCRIPTION (provided by applicant): Fungal infections continue to be a major cause of morbidity and mortality among HIV-infected patients. Many of the emerging fungal pathogens that are resistant to the three classes of antifungal agents for AID-s-relatedinfections are becoming more common and are associated with higher rates of mortality. Combating drug resistant fungal pathogens should be a top ...