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The Award database is continually updated throughout the year. As a result, data for FY23 is not expected to be complete until September, 2024.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. SYSTEMIC RADIONUCLIDE THERAPY TARGETED TO VEGF RECEPTORS IN TUMOR VASCULATURE

    SBC: SIBTECH, INC.            Topic: NCI

    The overall goal of this collaborative project between SibTech Inc PI Backer J and Johns Hopkins University PI Pomper M is clinical development of efficient and cost effective anti angiogenic Lu radiopharmaceutical scV Lu for VEGF receptor mediated targeting of angiogenic tumor vasculature Current very expensive anti angiogenic compounds induce transient regression of tumor vascula ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  2. Discovery of Novel TLR Ligands with Adjuvant Properties

    SBC: VAXINNATE CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): The interactions of Toll-like receptors (TLR) with their cognate ligands, Pathogen-Associated Molecular Patterns (PAMPs), trigger the immediate response of the innate immune system and set off a cascade of events t

    SBIR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  3. Antivirals Targeting Flavivirus Envelope Proteins

    SBC: L2 DIAGNOSTICS LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop therapeutic antivirals to treat life-threatening flavivirus infections. Enfuvirtide, a clinically successful peptide HIV fusion inhibitor, is the prototype for a new class of antivirals that inhibit viral envelope protein structural rearrangements essential for viral entry into host cells. In preliminary experiment ...

    STTR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  4. Antivirals Targeting Flavivirus Envelope Proteins

    SBC: L2 DIAGNOSTICS LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop therapeutic antivirals to treat life-threatening flavivirus infections. Enfuvirtide, a clinically successful peptide HIV fusion inhibitor, is the prototype for a new class of antivirals that inhibit viral envelope protein structural rearrangements essential for viral entry into host cells. In preliminary experiment ...

    SBIR Phase I 2006 Department of Health and Human ServicesNational Institutes of Health
  5. Antibody Prophylaxis and Therapy of Flavivirus Infection

    SBC: L2 DIAGNOSTICS LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The overall goal of this project is to develop antibody therapy and prophylaxis to treat and prevent life-threatening flavivirus infections. West Nile virus is the focus of Phase I studies. Our working hypothesis is t

    SBIR Phase I 2004 Department of Health and Human ServicesNational Institutes of Health
  6. Needle-Implantable, Wireless Multi-Sensor for Continuous Glucose Monitoring

    SBC: Biorasis            Topic: N/A

    DESCRIPTION (provided by applicant): Background: Over the past five years, the University of Connecticut together with its start-up spin-off corporation (Biorasis Inc.) has been developing a totally implantable biosensor platform (0.5 mm x 0.5 mm x 5 mm) capable of continuously monitoring glucose. The underlying principle in developing this miniaturized sensor hinges on extreme miniaturization uti ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  7. Automated Parkinson's Disease Dopamine Transporter Scan Analysis Fast Track

    SBC: Molecular Neuroimaging, L.l.c.            Topic: N/A

    DESCRIPTION (provided by applicant): We hypothesize that for a class of dopamine transporter SPECT agents, an automated software processing package can be developed, which will objectively yield striatal quantitative uptake values for evaluating Parkinson' s disease (PD) diagnosis and progression. This fully automated and Objective Striatal Analysis (OSA) package will be able to evaluate subjects ...

    STTR Phase I 2007 Department of Health and Human ServicesNational Institutes of Health
  8. Nanostructure Array Integrated Medical Mask Design with High Filtration, Low Breathing Resistance, and Antimicrobial Performances

    SBC: 3D ARRAY TECHNOLOGY LLC            Topic: 2

    Herein, 3D Array Technology LLC aims to develop a new type of nanostructure array (nanoarray) integrated microfibers to enable the medical masks with high filtration efficiency, low breathing resistance, and good antimicrobial capabilities. By integrating multifunctional nanoarray coatings onto the polypropylene microfibers through a scalable hydrothermal process, the surface area and roughness of ...

    SBIR Phase I 2022 Department of CommerceNational Institute of Standards and Technology
  9. Silencing cardiac-specific microRNAs to prevent pathological remodeling in conges

    SBC: Virscio Inc            Topic: NHLBI

    DESCRIPTION (provided by applicant): Heart disease remains the primary cause of morbidity and mortality in the industrialized world and continues to incur costs estimated at 30 billion per year, despite detailed understanding of the mechanisms governing cardiac function and contractility. MicroRNAs (miRNAs), a recently discovered family of tiny regulatory RNAs, act as negative regulators of gene ...

    SBIR Phase I 2011 Department of Health and Human ServicesNational Institutes of Health
  10. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury

    SBC: KOVOGEN            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal describes the development of hyperpolarized-129Xenon (HP-Xe)-based probes for magnetic resonance imaging (MRI) of two biomarkers of inflammation and brain injury, the peripheral benzodiazepine receptor (PBR) and the neurotrophic protein, S100B. Molecular imaging (MI) is an emerging discipline that tries to non-invasively visualize specific biomole ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
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