Award Data

1 Approximately 6.5 million Americans aged 65 and older live with dementia, supported by more than 11 million2 unpaid family caregivers. These numbers are projected to rise exponentially in the coming decades fueling the3 need to develop scalable ways to support dementia caregivers. The need to empower dementia caregivers to4 continue providing care while maintaining their own health and well-bein ...

Project summary Adoptive cell therapy has revolutionized cancer treatment and has immense potential to cure a variety of cancer types. Multiple critical barriers exist for current CAR-T therapy particularly in solid tumor, including insufficient T cells trafficking to the cancer site, lack of effective cancer cell killing, severe toxicity, strong immunosuppression in the tumor microenvironment, an ...

The TONE Knows Inc. ("TONE") will develop next-generation warehouse inventory management, verification, location, and reconciliation utilizing our patented "audio QR Code" technology. This technology allows for the continuous monitoring, tracking, and accounting for every single item stored in a DLA DC, external storage areas, in-theater Distribution Centers, or forward storage facilities, util ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project focuses on the unique combination of cancer-specific antibodies and adoptive Natural Killer (NK) immune cells needed to offer personalizable cancer therapies.This innovation represents a platform technology that can spawn multiple innovative cancer treatments, which could positively impact lif ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is the extension of state-of-the-art terrestrial 5G technologies to non-terrestrial satellite networks. Non-terrestrial networks (NTNs) are the ideal hosts for many commercial applications involving monitoring, reconnaissance, and remote sensing such as agricultural planting, remote factory op ...

SUMMARY Pantothenate kinase-associated neurodegeneration, PKAN, is a rare progressive neurodegenerative disorder associated with iron accumulation in the brain. The disease causes early immobility and often death by early adulthood. PKAN is caused by mutations in one of four human pantothenate kinase genes, PANK2 gene, which encodes a mitochondrial pantothenate kinase. Consistent with the clinical ...

Abstract The success of cohort studies such as the NIDDK Kidney Precision Medicine Project (KPMP) with its massive amount of samples depends on the cost and time-efficient evaluation of kidney biopsies at multiple scales. Assessing the structure of kidney tissue at the nanoscale (~10 nm) and evaluating the 3-D distribution of protein biomarkers in that context is, however, currently severely limit ...

Sonalysts, Inc. (Sonalysts) proposes a portable expeditionary unit that can deliver Undersea Warfare Decision Support System (USW-DSS) training to the Fleet via an orchestrated containerized system with an integrated training management application to track operator completion and launch training content. Sonalysts’ solution will also include Artificial Intelligence/Machine Learning (AI/ML) base ...

PROJECT SUMMARY Over 10 million women in the US and 100 million women globally suffer from Heavy Menstrual Bleeding (HMB). Oral medications lack effectiveness and, like hormonal IUDs (intrauterine devices), have significant side effects. Currently available endometrial ablation options, which is another therapeutic alternative, are complex and require advanced anesthesia, which significantly limit ...

The WCH serious gaming solution can close the gap between DoD civilian healthcare employees and the active-duty/retiree community they serve. By fostering a safe learning environment, culturally sensitive communication skills, and willingness to learn fro