Award Data

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will result from improving the quality of healthcare in the United States and reducing the associated costs for common elective surgery procedures through evidence-driven patient-physician matching. This technology will improve the quality of care and reduce the variation in costs associated w ...

Project Summary Abstract Acute lung injuryALIor Acute Respiratory Acute Respiratory Distress SyndromeARDSare characterized by an increased permeability of the alveolar capillary barrier resulting in lung edema with protein rich fluidthus resulting in impairment of arterial oxygenationLung edemaendothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and b ...

An overarching factor in the development of any successfulartificial pancreassystem is the advancement of a highly accurate and long lived glucose sensorwithout the need for numerous recalibrationsFrequentlyimplantable glucose sensors demonstrate insufficient reliability with respect to performanceaccuracy and response timewhich is thought to be the result of poor biocompatibilityCentral to these ...

PROJECT SUMMARYABSTRACT Cardio pulmonary diseases are the leading cause of morbidity and mortality worldwideDespite recent advances in drug therapy and improvements in patient carecardio pulmonary diseases remains a fatal diseaseAngiotensin converting enzymeACEand angiotensinAngprotective axis of the renin angiotensin systemRAShas emerged as highly effective in producing beneficial effects on meta ...

PROJECT SUMMARY The goal of this study is to develop an objective tool for the fast and easy assessment of strokeby developing a novel analytics platform that quickly identifies potential stroke from movement signatures captured with wearable sensorsThe tool uses unobtrusive wearable sensors and does not require medical training to operateand thus will be valuable for families and caregivers of ol ...

The GoalTo improve patient safety and outcomes for all modalities of external beam radiation therapy in a cost effective manner by using a new type of HDD pre treatment Patient Specific Quality AssurancePSQAProduct to be Developed by the end of Phase IIThe CrystalBallSystemwill consist of a fully robotized fast laser CT of low cost reusable radiochromic polymer gel dosimetersIt will detect and cor ...

GravesdiseaseGDis the most common cause of hyperthyroidism and is caused by stimulation of the thyroid stimulating hormone receptorTSHRby thyroid receptor stimulating antibodiesTSAbsTreatment of GD involves antithyroid medication therapyradioactive iodineand surgeryAt the presentfew alternative forms of therapy for GD are available or are in developmentThe ability to block TSHR action may also be ...

ABSTRACT This Phase I STTR is designed to evaluate the feasibility of using the OsteoFabtechnology platform for joint arthroplastyArthroFabdevicesspecifically targeting replacement of the small carpal bones in the wrist and hemiarthroplastyOsteoFabtechnology is the combination of Oxford Performance Materialsandaposproprietary formulation of polyetherketoneketoneOXPEKKpolymerand additive manufactur ...

PROJECT SUMMARY ABSTRACT The performance of many x ray imaging systems is limited by the lack of x ray detectors with simultaneous high quantum efficiency and high spatial resolutionAs examplesdigital mammography scanners typically have a resolution ofm for high quantum efficiencywhich is not sufficient to effectively detect small but critical microcalcificationsX ray micro CT scanners either use ...

Abstract Stress urinary incontinenceSUIcan result from a combinatorial neuromuscular injury to the pudendal nerve and the muscle it innervatesthe external urethral sphincterEUScompounded by the biochemical effects of agingThe mechanisms of SUI development include incomplete pudendal nerve regeneration and EUS sphincter repair from the maternal polytrauma of childbirth as well as biochemical change ...