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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Cytomegalovirus-based therapeutic vaccine for chronic hepatitis B

    SBC: TOMEGAVAX, INC.            Topic: R

    Abstract Although an efficient prophylactic vaccine is available for hepatitis B virusHBVchronic hepatitis BCHBaffects up tomillion people worldwideand despite advances remains mostly incurableIn adultsacute HBV infection is cleared inof cases by CDT cell mediated mechanismsbut chroniclifelong infection ensues in the remaining individualswhich can lead to liver cirrhosis and cancerThe induction an ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Advancing Human Health by Lowering Barriers to Electrophysiology in Genetic Model Organisms

    SBC: NEMAMETRIX, INC            Topic: 300

    Project Summary The nematode worm Caenorhabditis elegans has proven valuable as a model for many high impact medical conditionsThe strength of Celegans derives from the extensive homologies between human and nematode genesand the many powerful tools available to manipulate genes in Celegansincluding expressing human genesResearchers utilizing medical models based on Celegans have converged on two ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. A Noninvasive Portable Device to Evaluate Feeding Problems in Infants

    SBC: Metabolic Nutritionals, Inc.            Topic: NICHD

    DESCRIPTION (provided by applicant): Feeding problems are a frequent harbinger of nascent neurological damage and are a major obstacle in transitioning infants from hospital nursery to discharge. Severe problems often require repeated hospitalization and tube feeding. Refractory feeding problems contribute significantly to the high cost of health care. Dysfunctional sucking in the newborn, in the ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  4. A Novel Approach for Real-time Proteomics in Live Cells

    SBC: POWERHOUSE PROTEOMIC SYSTEMS LLC            Topic: NCRR

    DESCRIPTION (provided by applicant): The ultimate goal of this SBIR project is to develop a novel proteomic system that will enable the real- time expression profiling of proteins in live murine embryonic stem (mES) cells and in differentiated cells derived there from. The first step involves the establishment of a library of fluorescent trap mES cell lines, each of which will harbor a single fluo ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Arsenic Selective Ligand-Anchored Fiber for Purification of Drinking Water

    SBC: Chemica Technologies, Inc            Topic: NIEHS

    DESCRIPTION (provided by applicant): Today, arsenic (As) poisoning is one of the major environmental threats worldwide as millions of human beings have been exposed to excessive arsenic through contaminated drinking water. The serious toxicity of arsenic has been well documented. Worldwide, communities demand novel separation technologies for the removal of arsenic from drinking water. Conventiona ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  6. Chitosan Gastrointestinal Hemostatic Dressing

    SBC: TRICOL BIOMEDICAL, INC            Topic: 200

    AbstractSerious non variceal upper gastrointestinal bleedingNVUGIBis a major cause of morbidity and mortality worldwideIncidence of NVUGIB in the US is close toevents peradultswith approximatelyhospital admissions annuallyUS treatment and prevention of NVUGIB continues to be a major medical emergencycostingmillion dollars every yearFailure in standard of care for NVUGIB results in mortality rates ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Clinical Cytometry Analysis Software with Automated Gating

    SBC: TREE STAR, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): Flow cytometry is used to rapidly gather large quantities of data on cell type and function. The manual process of classifying hundreds of thousands of cells forms a bottleneck in diagnostics, high-throughput screening, clinical trials, and large-scale research experiments. The process currently requires a trained technician to identify populations on a digital ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  8. Commercial Software for Modeling of G Protein-Coupled Receptors

    SBC: SCHRODINGER, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Dysfunction of G protein-coupled receptors (GPCRs) results in diseases as diverse as Alzheimer's, Parkinson's, diabetes, dwarfism, color blindness, retina pigmentosa and asthma. GPCRs are also involved in depression, schizophrenia, sleeplessness, hypertension, impotence, anxiety, stress, renal failure, several cardiovascular disorders and inflammations. Unfortu ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  9. Confocal and Autofluorescence Imaging of Macular Degeneration using a Low Cost Digital Imager

    SBC: AEON IMAGING LLC            Topic: NEI

    Project SummaryAbstract The overall goal of the proposed SBIR Phase II research is to build and evaluate a low costmulti mode retinal camera used to detect and manage causes of macular impairmentAge related macular degenerationAMDremains the most common cause of permanent vision loss in the US and many industrialized countriesTreatments with portable lasers and injectable drugs can save sightbut e ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Development of a novel bioabsorbable clip and applier for rapid closure of the dura mater in open and minimally invasive spine surgery.

    SBC: NeuraMedica Inc.            Topic: NINDS

    PROJECT SUMMARY ABSTRACT This Small Business Innovation Research Phase II project supports the development of a novel bioabsorbable surgical clip and applier for rapid closure of the dura mater in open and minimally invasive spine surgeryThe dura mater is the protective membrane that covers the brain and spinal cord and contains cerebrospinal fluidCSFOpenings in the duradurotomycan result in CSF l ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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