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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. An Automated Early Motor Development Risk Screener from Observational Video Recordings of Infants and Toddlers

    SBC: BSOLUTIONS, INC.            Topic: NICHD

    Motor development plays a pivotal role in an infant’s overall development and has a cascading effect on social, cognitive, memory, and language ability. These functions can be compromised when motor development is disrupted; motor disruption is associated with generalized developmental delays. Early screening and identification of delays can allow early interventions with the goal of not just im ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Phase 1 Clinical Trial Evaluating the Novel Small Molecule Immuno-Oncology Antagonist SX-682 Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCR1 and CXCR2 (CXCR1/2) are validated as having essential roles in the growth, survival, motility, invasion and angiogenesis of human melanoma, which secretes abundant amounts of the corresponding chemokine ligands, including CXCL8. Additionally, abnormal cancer-induced immunosuppressive myeloid-derived suppressor cells (MDSCs) in the circulation and tumor correlate with ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Optimization and Validation of an indicator cell assay for blood-based diagnosis of lung cancer

    SBC: PRECYTE INC            Topic: 102

    Project Summary. The Indicator Cell Assay Platform (iCAP) is an inexpensive blood-based assay that can be used for early detection of disease, disease stage stratification, prognosis and response to therapy for a variety of diseases. The iCAP uses cultured, standardized cells as biosensors, capitalizing on the ability of cells to respond to disease signals present in serum with exquisite sensitivi ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Pdot-Enabled Point-of-Care Digital PCR for Sensitive Detection of SARS-CoV-2

    SBC: LAMPROGEN INC            Topic: 400

    Project Summary Current SARS-CoV-2 molecular diagnosis tests mostly are based on real-time quantitative PCR (qPCR). Digital PCR is a next-generation PCR technology based on limiting dilution, end-point PCR, and Poisson statistics. Digital PCR transforms the exponential, analog nature of qPCR quantification into a linear, digital signal quantification. Compared to qPCR, digital PCR offers several i ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Expanding the Click City: Tobacco Prevention Program to Include E-cigarettes and Other Novel Tobacco Products

    SBC: OREGON RESEARCH BEHAVIORAL INTERVENTION STRATEGIES, INC.            Topic: NIDA

    While the prevalence of smoking has decreased among youth, the prevalence of e-cigarette (e-cig) use has recently increased dramatically, greatly exceeding that of cigarette use. The increased prevalence of e- cig use among youth, the health effects of e-cigs, and the increased probability that adolescents will become addicted to nicotine through the use of e-cigs provide support for the crucial n ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Optimization and Validation of an Indicator Cell Assay for Blood-Based Diagnosis of Alzheimer's Disease

    SBC: PRECYTE INC            Topic: NIA

    Project Summary. PreCyte is developing the Indicator Cell Assay Platform (iCAP) as a broadly applicable and inexpensive blood-based assay that can be used for the early detection of disease, disease stage stratification, prognosis and predicting response to therapy for a variety of diseases. The iCAP uses cultured, standardized cells as biosensors, capitalizing on the ability of cells to respond t ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  7. Confocal and Autofluorescence Imaging of Macular Degeneration using a Low Cost Digital Imager

    SBC: AEON IMAGING LLC            Topic: NEI

    Project SummaryAbstract The overall goal of the proposed SBIR Phase II research is to build and evaluate a low costmulti mode retinal camera used to detect and manage causes of macular impairmentAge related macular degenerationAMDremains the most common cause of permanent vision loss in the US and many industrialized countriesTreatments with portable lasers and injectable drugs can save sightbut e ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  8. Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein-protein interaction

    SBC: ANAGIN            Topic: 103

    Abstract This application, “Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein- protein interaction,” addresses the critical need for more effective medications to treat chronic neuropathic pain affecting ~116 million people in the United States. Current pain medications such as NSAIDS, steroids, opiates and gabapentin analogs have documented and often severe sid ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Chitosan Gastrointestinal Hemostatic Dressing

    SBC: TRICOL BIOMEDICAL, INC            Topic: 200

    AbstractSerious non variceal upper gastrointestinal bleedingNVUGIBis a major cause of morbidity and mortality worldwideIncidence of NVUGIB in the US is close toevents peradultswith approximatelyhospital admissions annuallyUS treatment and prevention of NVUGIB continues to be a major medical emergencycostingmillion dollars every yearFailure in standard of care for NVUGIB results in mortality rates ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  10. Early Detection of Ovarian Cancer Using Uterine Lavage and Duplex Sequencing

    SBC: TWINSTRAND BIOSCIENCES INC            Topic: 102

    Nearly a quarter of a million new cases of ovarian cancer are identified every year worldwide and the majority of these woman will die from their disease. When detected early, surgical cure rates exceed 90%, but currently most cases are detected at an advanced stage when the cancer has already disseminated. As such, our most pressing problem in ovarian cancer is a lack of tools to identify early s ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
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