Award Data

DESCRIPTION (provided by applicant): The overall goal of the proposed SBIR program is to implement and evaluate a low cost retinal camera, the Laser Scanning Digital Camera (LSDC), in a system for diabetic retinopathy (DR) screening. Untreated DR has reached epidemic levels in underserved populations worldwide. As the LSDC has already demonstrated its readiness for DR screening in preliminary stud ...

DESCRIPTION (provided by applicant): The ultimate goal of this SBIR project is to develop a novel proteomic system that will enable the real- time expression profiling of proteins in live murine embryonic stem (mES) cells and in differentiated cells derived there from. The first step involves the establishment of a library of fluorescent trap mES cell lines, each of which will harbor a single fluo ...

This project involves a feasibility study for a rapid scanning near-infrared/infrared spectrometer for transient, simultaneous measurements of CO2 and H20 concentrations, soot volume fractions and temperatures. Such measurements can lead to improved understanding of the structure of turbulent and laminar flames. A commercial instrument that can reliably provide simultaneous gas concentrtaion, so ...

Description (provided by applicant): High-Intensity Focused Ultrasound (HIFU) phased arrays allow flexibility in beam steering, beam shaping, and dynamic focusing. These features enable them to create large and contiguous tissue lesions of predetermined shape with high efficiency, resulting in shorter treatments, increased accuracy, and ease of operation. The g ...

DESCRIPTION(provided by applicant): The MUSE System delivers personalized experiences to museum visitors on a handheld tablet computer based on their preferences, special needs, and other contextual information. The system will be built on Universal Design standards and developed with user participatory design methods to help ensure the product will serve the bro ...

Phycotransgenics goal is to develop a vaccine delivery system using microalgae to reduce diseaseassociated costs for aquaculture. To accomplish this, we transformed Chlamydomonas, a single-cell algal species, with an antigen gene. Through our Phase 1 Program, we demonstrated that: 1) an antigen expressed in our algae can elicit an immune response in fish, and; 2) using our microalgal delivery syst ...

DESCRIPTION (provided by applicant): The rate of drug development is disappointingly slow, in part because of the failure of preclinical drug studies to elucidate the mechanisms of drug actions. INphoton has demonstrated that intravital microscopy can be used as a powerful tool in preclinical drug studies, providing the mechanistic insights typically associated with studies of cultured cells, but ...