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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 10484 results
  1. Small Molecule Treatments to Enhance Neurological Recovery After Stroke

    SBC: Stemetix, Inc.            Topic: NINDS

    PROJECT SUMMARYStroke is a major public health problem in the U Sand worldwideIt is defined as an area of brain damagegenerally due to the sudden occlusion of an artery in or leading to the brainStroke can cause weaknessnumbnessvisual disturbancespeech difficultybalance problemsand memory lossamong other symptomsWhile good treatments exist to limit stroke in the first few hours after occurrencefew ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Clinical optical coherence tomography for retinal metabolic imaging

    SBC: OPTICENT, INC.            Topic: NEI

    PROJECT SUMMARY Diabetic retinopathyDRis a complication of diabetes and a leading cause of blindness in the worldAlthough it is widely accepted that DR is driven by ischemiathe current grading of DR severity is based only on structural alterations such as the presence of abnormal retinal microvasculature in non proliferative DR or angiogenesis in proliferative DRAs a resultmost patients have alrea ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Multi-modal AO-LSO Phase Gradient Imaging of the Inner Retina

    SBC: MixZon, Inc.            Topic: NEI

    Project Summary Abstract Physical Sciences IncPSIis continuing the pursuit of new clinical applications and advanced multimodal capabilities for its novel retinal imaging technology based on an adaptive optics line scanning ophthalmoscopeAO LSOThe Compact Adaptive Optics Retinal ImagerCAORIeliminates high speed scanning componentsreduces the clinical footprint compared to research adaptive optics ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Advanced Indoor Navigation Aid for Blind and Visually-Impaired Individuals in Unfamiliar Spaces

    SBC: Vortant Technologies, LLC.            Topic: N

    Project Summary Abstract Confusionbeing lostand losing track of oneandapos s orientation within large or unfamiliar indoor spacesthese are some of the biggest challenges facing people with visual disabilitiesSince GPS typically doesnandapos t work indoorsand isnandapos t fine grained enough anywayindividuals who cannot readily access visual information are at a significant disadvantageand many bli ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. CometChip: Development of a high throughput DNA damage assay in hepatocytes

    SBC: INTEGRATED LABORATORY SYSTEMS, INCORPORATED            Topic: NIEHS

    An estimatedanimals are used in toxicology safety assessments to meet all regulatory requirements with testing spanningtoyrs and exceeding $million dollarsThere is a critical need to reduce reliance on animal testing and to develop highly predictive human based biological models for safety assessmentsReplacement of traditional animal toxicity tests for toxicology safety assessments with alternativ ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein-protein interaction

    SBC: ANAGIN            Topic: 103

    Abstract This applicationDevelopment of novel small molecule analgesics modulating the nNOS NOS AP proteinprotein interactionaddresses the critical need for more effective medications to treat chronic neuropathic pain affectingmillion people in the United StatesCurrent pain medications such as NSAIDSsteroidsopiates and gabapentin analogs have documented and often severe side effectsare poorly effe ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Enhanced Treatment Management of Opioid-Dependence in an Office-Based Setting

    SBC: MedicaSafe Inc            Topic: NIDA

    PROJECT SUMMARY ABSTRACT Opioid use disorder is the leading cause of accidental death in the USwith overlethal drug overdoses inSAMHSA estimates thatmillion Americans misuse prescription opioids for non medical purposes annuallyPublic health officials and policymakers have acknowledged the urgent need for innovative approaches to the treatment of those with opioid use disorderin spite of thisthe a ...

    SBIR Phase II 2018 Department of Health and Human Services
  8. AD-MS Chips for Biofluids-Based Diagnosis of Alzheimer's Disease

    SBC: Newomics Inc            Topic: NIA

    Project Summary Abstract Alzheimerandapos s diseaseADis a devastating neurodegenerative disease that affects more thanmillion peopleincludingmillion Americansworldwideand this number is expected to reach more thanmillion by the yearRecent disappointing results from a large number of clinical trials for AD treatment further aggravate the problemOne major challenge is there is currently no blood bas ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Automated Assessment of Leptomeningeal Collaterals on CT Angiograms

    SBC: Kitware, Inc.            Topic: 108

    AbstractThe primary goal of this study is to develop an automated scoring system of leptomeningeal collaterals based on CT angiographyCTAas a quantitative assessment of acute ischemic strokeLeptomeningeal collaterals provide an alternate path of blood flow in the setting of a proximal vessel occlusionThe presence and effectiveness of leptomeningeal collateralsi ecollateral statusvaries significant ...

    STTR Phase II 2018 Department of Health and Human Services
  10. A technology solution for peer-led Seeking Safety

    SBC: LMN CONSULTING            Topic: NIDA

    AbstractPeers are increasingly recognized as an important asset in healthcarePeer support is historically most prominent for substance use disorderSUDsuch as the world wide model of Alcoholics Anonymous and otherstep groupsYet for trauma and posttraumatic stress disorderPTSDthere have been few attempts at peer helpA major challenge of trauma peer groups is that they usually focus on telling the st ...

    SBIR Phase II 2018 Department of Health and Human Services

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