Award Data

Phase II goals will be to: 1. To develop a production version of an Integration toolkit (ITK) that can deployed at low cost to clinics using spina bifida EMR (to improve the efficiency of their participation in the NSBPR) 2. To pilot the ITK at selected SB-EMR clinics 3. To evaluate the impact of the production version of the ITK The ITK will be developed based on design principles & specifica ...

Increasing girls' access to medically accurate, comprehensive & confidential sexual health information is critical in sustaining the momentum in teen pregnancy reduction. Our goal is to put the power of sexual health information in English & in Spanish in the hands of millions of girls through Crush 2.0 a youth-engaging mobile application grounded in the Theory of Planned behavior and self-effi ...

To improve the safety and efficacy of oral rotavirus vaccines, CDC scientists have developed a proprietary inactivated rotavirus vaccine (IRV) technology (new human strains and a novel method for rotavirus inactivation) and demonstrated the immunogenicity in mice [14] and protective efficacy in piglets [15] of this IRV by intramuscular (IM) administration. More recently, CDC scientists have demons ...

DESCRIPTION (provided by applicant): According to the National Survey of Drug Use and Health (NSDUH) of 2008, 7.2 million Americans are in need of treatment for Substance-Related Disorders (SRDs), and a large proportion of those need treatment for opiate pain reliever, heroin, and alcohol addiction. Naltrexone (NTX), an opioid antagonist, is currently used in oral tablet form to help maintain opio ...

DESCRIPTION (provided by applicant): Lipella Pharmaceuticals Inc. (Pittsburgh, PA) is a clinical-stage pharmaceutical company specializing in intravesical therapies for urinary bladder dysfunctions. Lipella is submitting a research proposal to the Small Business Technology Transfer program titled Developing Intravesical Liposomes for Interstitial Cystitis . The project proposes to evaluate the sa ...

DESCRIPTION provided by applicant The congenital long QT syndrome LQTS is thought to occur in in infants and cause of deaths from SIDS sudden infant death syndrome Electrocardiograms ECGs can detect LQTS before fatal cardiac events happen In our Phase I STTR project we successfully developed and tested an ECG device designed for LQTS screening in newborns This device n ...

DESCRIPTION (provided by applicant): Heart failure (HF) is a major health problem in the US and worldwide. Over 100,000 people in the US are diagnosed with end stage HF annually. Heart transplantation is performed in only 2% of these cases due to lack of available donor hearts. Mechanical left ventricular assist devices (LVADs, a type of artificial heart) can allow patients with severe HF to live ...

This contract addresses the need for reliable and accurate biomarkers of alcohol consumption, initially in response to a National Institute on Alcohol Abuse and Alcoholism (NIAAA)-initiated Small Business Innovation Research (SBIR) contract topic on Biomarkers for Alcohol-induced Disorders. The goals of this contract are to advance the usefulness of phosphatidylethanol (PEth), an alcohol metabolit ...

This project aims to optimize the lead formulation of epothilone D encapsulated in a stable nanoparticle for the treatment of solid malignancies, and assist in providing for the GMP manufacturing and GLP toxicology studies required for IND submission and translation into human clinical trials. The optimized formulation should demonstrate improvements in plasma pharmacokinetics in a cannulated rat ...

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