Award Data

Multidrug resistant (MDR) bacterial wound infections remain a persistent challenge for front-line military medical providers in prolonged care treatment. Bacteriophage (phage) therapeutics have demonstrated preclinical and clinical efficacy against ESKAPEE infections. Phage production however remains a challenge to remove common pyrogen contaminants from phage products, including endotoxins (lipop ...

Bacteriophages (phages) are becoming important therapeutic candidates against multidrug resistant (MDR) bacterial infections. There is a need to isolate and concentrate phages collected from the field to enhance specimen storage stability for long-distance transport to specialized laboratories for subsequent analysis. Environmental phage preparation requires expensive, bulky instrumentation and in ...

To defeat OP nerve agents, we must match both their potency and access to the synaptic cleft. Unfortunately, the most potent organophosphate antidotes cannot access neurons from the systemic circulation. Phosphotriesterase (PTE) enzyme mutants are too large, and small, cationic oximes are too charged to cross the blood-brain-barrier or blood-nerve-barrier in appreciable quantities. State-of-the-ar ...

In response to DHA202-002, SunFire Biotechnologies (SFB) proposed to develop a 2-fold multiplexed serum bactericidal assay (mSBA) for Shigella antibodies and to demonstrate its operational feasibility.  With that Phase I funding, SFB developed a 4-fold mSBA, based on antibiotic resistance, which allows the simultaneous testing of functional antibodies against S. flexneri serotypes 2a, 3a, and 6, ...

The twenty-first century has seen a global rise in bacterial infections exhibiting antimicrobial-resistance (AMR). More than ninety percent of chronic wounds contain microbial biofilms that exhibit AMR, and the bacteria responsible for several of these recalcitrant infections are called ESKAPEE pathogens. Eradicating ESKAPEE pathogenic infections is challenging, but bacteriophage (phage) therapy i ...

RF weapons are an emerging battlefield threat. These directed energy weapons are being demonstrated at higher power levels and in smaller, less costly, and more mobile platforms. However, while the defense industry is just now beginning to understand the effects of high-levels of RF energy on electronic systems, through rigorous test and evaluation of instrumented targets and systems, there is sig ...

Virtual human avatars will play a critical role in the next generation of advanced training environments, performance-related physiological modeling, and simulation-based design of protective armor. The overall goal of this project is to design and develop computer software for generating dynamic, mission-relevant avatar movements utilizing USARIEM’s static finite element avatars. During the ini ...

An approved high-level-disinfection-and-sterilization portable kit is developed that requires the minimum of resources to be used for a mass casualty, resource stressed field hospital scenario. The focus is on sterilization of hinged, narrow channel scope instruments, vital tools when delivering care, which can harbor organic material and bacteria. Power, time,  and staff resources pose challenge ...

In the proposed Phase II Extension (Phase II E), we will develop and deploy a software product, Personalized CoBi-Blast and a cloud database for monitoring of repeated blast loads on Service members involved in heavy weapons training using data collected from wearable pressure sensors (blast gauges). The work in the proposed Phase II E project will focus on: • Monitoring of the repeated exposure ...

GeneCapture proposes to develop and test an automated wound pathogen identification (ID) and Antibiotic Susceptibility Test (AST) system with strong dual-use potential in both the Military and Commercial Point-of-Care markets. The TRL6 ID test will distinguish multiple pathogens from the same sample using the company’s patented CAPTURE (Confirming Active Pathogens Through Unamplified RNA Express ...