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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. 3D Microfluidic Platform for in vitro Hematopoietic Stem Cell (HSC) Culture

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD10103

    Poor drug candidates are often identified late in the drug development process (e.g., in the preclinical and clinical phases) and contribute significantly to the high cost and low yield of drug discovery. As a result, new tools are needed to accelerate the assessment of drug candidate toxicity earlier in the drug development process. To address this Chemical/Bio Defense (CBD) need, Physical Optics ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  2. 3D Scaffold and Stem Cell Based Bioengineered Skin for Treatment of Cutaneous Vesicant Injury

    SBC: Nomadics, Inc.            Topic: CBD05117

    In this Phase II project Nomadics will novate our research to a spin-out company Nico Technologies. Nomadics will remain a subcontractor during this transition. The team proposes a new treatment for injuries from mustard gas based on biodegradable inverted colloidal crystal scaffolds impregnated with stem cells. Phase I results demonstrated excellent performance of these scaffolds for different ...

    SBIR Phase II 2007 Department of DefenseOffice for Chemical and Biological Defense
  3. A High-Throughput Blood Esterase Panel Assay

    SBC: AGAVE BIOSYSTEMS INC.            Topic: CBD10108

    Organophosphorus chemical warfare nerve agents (OP-CWA) are attractive to terrorist groups and rogue states as an inexpensive and accessible technology for chemical warfare. OP-CWA and organophosphate pesticides cause severe neurological symptoms and death by inhibiting the enzyme acetylcholinesterase (AChE); the resulting excess acetylcholine accumulates and overstimulates the human or animal bo ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  4. A Low-Cost, High-Performance Colloidal Quantum Dot LWIR FPA for Hyperspectral Imaging

    SBC: SIVANANTHAN LABORATORIES, INC.            Topic: CBD13105

    The primary goal of this proposed work is to develop a long wavelength infrared (LWIR) colloidal quantum dot (CQD)-based focal plane array (FPA) and show its feasibility when used in a camera system and a hyperspectral imaging system. Phase I results cumulated in the first-ever synthesis of photoresponsive LWIR CQDs and CQD-based photodetectors at the single device level operating at room temperat ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  5. A Miniature Autoinjector for Multicomponent Drugs and Vaccines

    SBC: CREARE LLC            Topic: CBD13106

    Chemical, biological, or toxin attacks in military and civilian settings are a serious and growing concern. Standard first aid for exposure to some chemical warfare agents and toxins includes the immediate administration of relevant antidotes using an autoinjector. When an attack occurs, pre-filled autoinjectors must be immediately available and thus highly portable, and they must be suitable fo ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  6. A Novel Microfludic Device for Drug Toxicity Studies

    SBC: CFD Research Corporation            Topic: CBD10103

    Current drug discovery and development efforts are severely limited by expensive animal trials and oversimplified in vitro models. Results obtained from in vitro models are not predictive of in vivo toxicity owing to significant difference from the in vivo physiological conditions. In this context, we propose to develop and demonstrate a novel microfluidic device that reproduces the physiological ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  7. A Novel, Aerodynamics-augmented Continuous Ionization System for Electrostatic Collection of Bioaerosols

    SBC: CFD Research Corporation            Topic: CBD12107

    Safe and efficient ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these limitations, we propose to develop and demonstrate a novel bioaerosol ionization and collectio ...

    SBIR Phase II 2014 Department of DefenseOffice for Chemical and Biological Defense
  8. A uMECS miniature blower for respiratory protection systems, Phase II

    SBC: Vibrant Composites Inc.            Topic: CBD14103

    Air management solutions capable of reducing heat and moisture burden are not suitable for integration in wearable respiratory protection systems due to excessive weight, volume, and power requirements of existing technologies. Vibrant Composites proposes applying its unique uMECS manufacturing technology towards development of an ultra-lightweight and power efficient miniature blower. Fundamental ...

    SBIR Phase II 2015 Department of DefenseOffice for Chemical and Biological Defense
  9. Accurate Real-time Methyl Salicylate Sensing System (ARMSSS)

    SBC: Intelligent Automation, Inc.            Topic: CBD09103

    Intelligent Automation Inc., proposed phase II approach and the demonstrated phase I prototype aims in the development of high sensitivity and selectivity for real time detection of Methyl Salicylate (MeS). In the phase I effort we demonstrated successfully: (1) Quartz Crystal Microbalance sensors for detection of MeS, (2) real time detection of change in concentration of MeS, (3) reuse of the Me ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  10. Adaptive Lens for Ocular Correction in Respiratory Protection Systems

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD152001

    To address the CBDs need for adjustable optical correction technology for respiratory protective systems, Physical Optics Corporation (POC)proposes to continue the development of a new low-cost Adaptive Lens for Ocular Correction (ALOC). The ALOC is formed by thin-filmmicroarrays of wavefront correctors (MWCs), which are conformably laminated onto the facemask visor and controlled by a miniature d ...

    SBIR Phase II 2017 Department of DefenseOffice for Chemical and Biological Defense

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