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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. Connective Tissue Motion Measure 2

    SBC: STROMATEC, INC            Topic: NCCAM

    DESCRIPTION (provided by applicant): Connective tissue dysfunction is emerging as a potentially important, and so far mostly overlooked, factor in the pathophysiology of chronic low back pain (LBP). We have developed and tested a novel instrument (StromaGlide) and test (Connective Tissue Motion Measure - CTMM) -quantifying the functional behavior of perimuscular connective tissues. The results of ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Targeted Treatment of Recurrent Small Cell Lung Cancer with Anti-AbnV2 Antibodies

    SBC: Woomera Therapeutics, Inc.            Topic: NCI

    DESCRIPTION (provided by applicant): There is currently no effective treatment for recurrent small-cell lung cancer (rSCLC). The objective of this project is to utilize a monoclonal antibody, Abner, to develop new, rational, and successful treatment of rSCLC. The hypothesis being tested is that an abnormal vasopressin type 2 receptor (AbnV2R) present on these tumors will provide a sensitive, tumor ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Software to Enrich the Noun Lexicons and Lexical Learning of Children with Autism

    SBC: LAUREATE LEARNING SYSTEMS, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): The objective of this project is to develop and field-test prototype software for a research-based vocabulary development program featuring a combined lexical-cognitive approach to noun acquisition. The target population for the curriculum will be 3-8 year old children with Autism Spectrum Disorders (ASD), as well as a broad range of other children with languag ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Dynamic Perturbation Training System for ACL Rehabilitation

    SBC: Simbex LLC            Topic: NICHD

    DESCRIPTION (provided by applicant): Anterior cruciate ligament (ACL) injuries are a significant problem for athletes, and women in particular. Both surgical and non-surgical treatment options exist, with the ultimate goal of regaining joint stability, knee kinematics, and quadriceps strength compared to the uninjured contralateral limb to allow full return of function and activity level and to p ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Depletion of Dendritic Cells by Immunotoxin as Therapy for Myocardial Infarction

    SBC: CELDARA MEDICAL, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): MI is the leading cause of death in the developed world, including the United States. In 2005 over 8.1 million Americans had an MI; 30% died before reaching hospital and 10% died after hospitalization. It is the 70% whoreach hospital that we believe we can help - a million lives in the balance and an improved quality of life for millions more - in the US alone. ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. ChNKG2D-Targeted Cellular Cancer Therapy: Phase I Clinical Trial

    SBC: CELDARA MEDICAL, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The global burden of cancer doubled between 1975 and 2000. Cancer became the leading cause of death worldwide in 2010, and is projected to double again by 2020 and to triple by 2030. This horrible disease has touched each of us, and despite enormous investments in prevention and treatment, its impact continues to accelerate. Ideally, any cancer therapy should ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. System for multidimensional analysis of growth and migration of neurons and neuro

    SBC: MICROBRIGHTFIELD, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): This project aims at developing the Orion microscope system, a highly innovative combined software/hardware product, which will facilitate automated investigations of dynamics of migration of neuronal precursors and neurite outgrowth in vitro using time-lapse video-microscopy (TLVM). To achieve this goal, the Orion microscope system will combine novel software ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. Ionomer-membrane Water Processor System Design and EDU Demonstration

    SBC: Paragon Space Development Corporation            Topic: X301

    a. Paragon Space Development Corporation¿ (Paragon) proposes to continue our investigation into the use of microporous-ionomer membrane technology to improve the robustness and effectiveness and simplify water recovery processes for space applications. Improved robustness and effectiveness will be evident through (1) reduced loading onthe downstream post processor due to the ionomer¿s unique pr ...

    SBIR Phase II 2012 National Aeronautics and Space Administration
  10. An Ultra Low Power Cryo-Refrigerator for Space

    SBC: CREARE LLC            Topic: S107

    Future NASA Space Science Missions will incorporate detectors, sensors, shields, and telescopes that must be cooled to cryogenic temperatures. An enabling technology for these missions is advanced cryocoolers that can provide continuous and distributed cooling with minimal input power. On this program, Creare proposes to develop and demonstrate an innovative cryocooler that produces refrigeratio ...

    SBIR Phase II 2012 National Aeronautics and Space Administration

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