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Quorum sensing (QS) allows bacterial populations to coordinate gene expression in a cell density dependent manner and plays a significant role in the onset of pathogenesis and biofilm development. In many Gram-negative bacteria, QS is mediated by signaling molecules called N-acyl-homoserine lactones (AHLs). We recently identified an AHL acylase from P. syringae which can enzymatically degrade and ...

DESCRIPTION provided by applicant The overall goal of this SBIR Phase II proposal is to develop and validate a fully commercialized instrumented gait analysis system and associated training and reporting tools Gait dysfunction can dramatically affect a personandapos s ability to perfor activities of daily living and assessment of gait is a critical component of physical therapy practice Cur ...

DESCRIPTION Infections are a leading cause of mortality in adult and pediatric ICUs Earlier diagnosis and treatment of infection could significantly reduce patient morbidity and mortality Unfortunately current methods of detection cannot routinely detect infection early in the disease course Isomark has developed a breath based early detection technology biomarkers and instruments for detect ...

Summary abstract The proteins encoded by the human genome may participate in as many as pairwise protein interactions and nearly every major process in a cell is carried out by assemblies of or more interlocking protein molecules Bruce Alberts Cell However there are no commercially available expression systems for regulated expression of multi subunit protein complexes The ...

DESCRIPTION provided by applicant Most drugs interact with protein molecules to elicit a cellular response Traditional drug discovery is a laborious and expensive experimental process so computational approaches to assess protein function and to accelerate the discovery process are in high demand Virtual drug screening and structure based drug design represent computational approaches that c ...

DESCRIPTION provided by applicant The surgeonandapos s choice of method for closing incisions is becoming increasingly problematic Metal surgical staples are unacceptable for Minimally Invasive Surgery MIS procedures currently percent of surgeries in the US and are out of favor in traditional procedures due to complications and the cost of staple removal Due to the time required for ma ...

DESCRIPTION provided by applicant All States have enacted laws providing for alcohol ignition interlocks as a sanction for impaired driving Going forward interlock programs may become as widely used with impaired drivers as license suspension even though they are more time consuming and expensive for the government to manage Although the extra expense of managing interlock programs is jus ...

DESCRIPTION provided by applicant Magnetic Resonance Imaging MRI has emerged in the past decade as an important tool for the detection diagnosis and management of breast cancer However the availability and reliability of MRI guided interventional procedures have lagged behind Currently ultrasound US image guided breast biopsy is favored by many clinicians for MRI detected lesions as i ...

DESCRIPTION provided by applicant Glioblastoma multiforme GBM or andquot glioblastoma andquot is the most common and aggressive malignant primary brain tumor in humans An effective treatment that increases patient survival would represent a significant advance in the field and provide a desperately needed new therapy for this deadly disease EnduRx is focused on the development of new tar ...

DESCRIPTION provided by applicant Significance Accurate targeting guidance and monitoring of interventional therapy in the brain are critical for maximizing their effectiveness and safety during and following neurosurgical procedures Magnetic resonance imaging MRI is a critical tool for planning and guiding neurosurgical procedures In most cases the MRI is obtained during a pre operative ...