Award Data

PROJECT SUMMARY This program aims to develop a novel non opioid therapeutic for the treatment of pain that targets a subtype of the human voltage gated Na ion channel NaV Preliminary data indicate that SiteOneandapos s lead drug candidates may be more effective than opioids for treating certain types of pain and lack the side effects associated with opioid analgesics which include nausea ...

The overall goal of this Phase II SBIR effort is to develop a three-wavelength, backscatter transceiver for in situ validation of ongoing High Spectral Resolution Lidar measurements. The key innovation in the effort is the use of a multi-element, non-linear waveguide for highly efficient, three wavelength generation in a collinear geometry ideally suited for use in the backscatter nephelometer at ...

The primary goal of the proposed STARA innovation is to develop and demonstrate a high altitude precision guided parafoil system that will enable NASA to control the final landing point of the sounding rocket payload, thus reducing system offset, recovery time, and recovery cost. Current recovery methods utilize unguided parachutes, which are susceptible to large uncertainties in recovery location ...

This Small Business Innovation Research (SBIR) Phase II project will develop and produce a robust, hand-held, video-rate three-dimensional surface metrology system with vertical and lateral resolution of several micrometers, in order to bridge a critical existing metrology gap for precision-machined surfaces. Many modern manufactured parts, such as turbine blades, drive shafts, orthopedics, and va ...

DESCRIPTION provided by applicant The human genome encodes protein kinases that catalyze the phosphorylation of client proteins Signal transduction mediated by protein impacts virtually all aspects of cellular physiology from the coordination of the cell cycle and cll division to apoptosis Not surprisingly the deregulation of kinases is implicated in many diseases including diabetes in ...

Principal Investigator Overstreet Derek J Abstract Sonoran Biosciences Inc SBIR PAR Direct Phase II Prosthetic joint infections PJIs are especially costly requiring two surgeries at a cost of approximately $ per case to treat more than hip and knee replacement infections each year The near term outlook in this area is bleak with the number of infections growing ov ...

Abstract It has become evident that the microvasculaturei emicroscopically small blood vesselsplays a critical role in the plasticity of the brain for fundamental processesineurogenesisiimigration of neuronal precursors to their final destination in the brainiiiaxonaldendritic and synaptic plasticity during brain developmentlearningaging and neurodegenerationandivrecovery from traumatic brain inju ...

Abstract This project aims to develop a novel systemSpines InvestigatorTMfor performing automated four dimensionalDquantitative analysis of changes in dendritic spine morphology on three dimensionalDmicroscopic images acquired with in vivo multiphoton fluorescence microscopy at different time pointsThe role of dendritic spines is one of the most active and important areas of neuroscience researchP ...

The problem: Currently in the US, there is not an affordable way to fulfill the need of high quality grafted vegetable transplants for field growers and hydroponic greenhouse growers. The key issues that intensify the problem are: 1) the large number of seedlings needed in a single batch (US large farming operations), 2) the current high price of grafted plants and 3) the proximity of seedling sup ...

In the DOE SBIR topic 24h, Accelerator Control and Diagnostics, the Office of Nuclear Physics seeks grant applications for the development of triggerable, high speed optical and/or IR cameras, with associated MByte- scale digital frame grabbers for investigating time dependent phenomena in accelerator beams. Image capture equipment needs to operate in a high-radiation environment and have a frame ...