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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. An Integrated Microarray Printing and Detection System

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. Tools for Accelerating R&D for Historically Understudied Protein Kinases


    Protein kinases are central players in almost every aspect of human physiology and serve as critical mediators of signal transductionThe dysfunction of many kinases is implicated in cancerdiabetesinflammationand cardiovascular diseases and many are validated targets for therapeutic interventionThe human genome encodesprotein kinasesYettheor so marketed protein kinase drugstarget only a small fract ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Preclinical development of PPCM vaginal contraceptive to submit IND.


    PROJECT SUMMARYThe goal of this project is to develop a novel vaginal contraceptive gel product containing PPCM sodium saltPPCMPPCM is a novel polymer drug that inhibits infection of HSVHIVNgonorrhea and is also contraceptiveThis novel drug has an average molecular weight ofis designed to be used topicallyand thus far passed all safety studies and does not appear to be systemically absorbedPPCM ha ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Development of New Improved Perflutren Ultrasound Contrast Agent


    Three ultrasound contrast agents Definity Optison and Lumason are FDA approved for echocardiography in the U S Definity currently has over market share Definity s dominance in the market is due to its ease of administration via IV infusion and robust ultrasound contrast Definity has shelf life of years and must be stored under refrigerated conditions Definity has an unpleasant ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Dynamic Flight Simulation Utilizing High Fidelity CFD-Based Nonlinear Reduced Order Model

    SBC: Zona Technology, Inc            Topic: A101

    The Nonlinear Dynamic Flight Simulation (NL-DFS) system will be developed in the Phase II project by combining the classical nonlinear rigid-body flight dynamics model with an add-on nonlinear aeroelastic solver to compute the airframe response due to pilot input command and to identify the key aeroelastic coupling mechanisms between the structural dynamics and unsteady aerodynamics with classic r ...

    SBIR Phase II 2017 National Aeronautics and Space Administration
  7. Compact High Pulse Energy Single Frequency Fiber Amplifier

    SBC: AdValue Photonics Inc            Topic: S101

    Atmospheric methane is the second most important anthropogenic greenhouse gas. The overtone lines of methane at 1.65 micron are well suited for remote sensing of atmospheric methane in the Earth?s atmosphere. NASA have already demonstrated ground-based and airborne methane detection using Optical Parametric Amplifiers at 1651 nm using a laser with a narrow linewidth. In this setup a single frequen ...

    SBIR Phase II 2017 National Aeronautics and Space Administration
  8. Low Coherence Wavefront Probe for Nanometer Level Free-Form Metrology

    SBC: APRE INSTRUMENTS, L.L.C.            Topic: S204

    We propose an innovative, low coherence probe for rapid measurement of free-form optical surfaces based on a novel method of spectrally controlled interferometry. The key innovations are the use of a new interferometric modality and a novel non-contact optical probe that together measure high surface slope acceptance angles to nanometer sensitivity. When the probe is integrated with a precision mo ...

    SBIR Phase II 2017 National Aeronautics and Space Administration
  9. Solar-Powered High-Efficiency CO2 Refrigeration Technologies


    SunDanzers High efficiency Refrigeration Unit (HERU) technology is a variable speed, two stage refrigeration platform, initially developed under Army SBIR topic A04-210, and continuing with Army Rapid Innovation Funding. HERU currently uses the military standard hydrofluorocarbon R-134a, vehicle type refrigerant. R-134a leaking into the atmosphere has 1400 times the greenhouse gas effect compared ...

    SBIR Phase II 2017 Department of DefenseArmy
  10. High-Sample Rate Analog to Digital Converters for Reconfigurable Phased Array Applications

    SBC: Alphacore, Inc.            Topic: SB153004

    Alphacore will develop and characterize a 40Gsps, 7-bit (ENOB = 6.0), low-power (480mW), 25GHz analog input bandwidth analog-to-digital converter (ADC) for use in configurable phased array applications in the defense sector. The proposed ADC employs an i...

    SBIR Phase II 2017 Department of DefenseDefense Advanced Research Projects Agency

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