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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Phage preparation for managing Salmonella in foods

    SBC: Intralytix Inc            Topic: 85

    Salmonellae continue to be one of the leading worldwide causes of foodborne bacterial diseases. They cause 1.2-1.4 million annual cases of salmonellosis in the USA, with associated costs estimated to be as high as $12.8 billion/year (in 1998 dollars). Despite continued and escalating efforts to curb diseases caused by foodborne bacterial pathogens, salmonellae continue to produce foodborne illness ...

    SBIR Phase II 2012 Department of Agriculture
  2. MyASL Quizmaker

    SBC: Institute For Disabilities Research & Training Inc            Topic: N/A

    Purpose: American Sign Language (ASL) is a visual and gestural language that is distinct from English, has its own grammar, syntax, vocabulary, and no text representation. Despite the differences between the languages, students who use ASL are typically assessed with protocols for English-speaking students, as few exist specifically for students who use ASL. Not surprisingly, prior research shows ...

    SBIR Phase II 2012 Department of Education
  3. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. IMPROVING MANUFACTURING AND POTENCY OF CRYOPRESERVED MALARIA SPOROZOITE VACCINE

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The development of Sanaria's aseptic, purified, cryopreserved Plasmodium falciparum (Pf) sporozoite (SPZ)-based products has received international recognition during the past year, due principally to four findings: 1)PfSPZ Challenge (infectious PfSPZ) induced malaria in volunteers, 2) PfSPZ Vaccine (radiation attenuated PfSPZ) induced unprecedented levels ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Transgenic Mosquitoes for Improved Malaria Sporozoite Vaccine Manufacture

    SBC: SANARIA INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): An ideal tool for eliminating Plasmodium falciparum (Pf), the causative agent of 99% of all malaria deaths, would be a highly effective vaccine that prevents blood stage infection and thereby prevents both disease and transmission. Sanaria's goal is to develop and commercialize a Pf sporozoite (SPZ) vaccine that prevents Pf blood stage infection in gt 90% ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. N-Methanocarbathymidine (N-MCT) for the treatment of herpes and pox virus infecti

    SBC: N&N Pharmaceuticals, Inc            Topic: NIAID

    DESCRIPTION (provided by applicant): Diseases associated with the Poxviridae (smallpox, vaccinia and cowpox viruses), and Herpesviridae (HSV-1, HSV-2, HSV-8, VZV, EBV) dsDNA viruses represent major worldwide public health problems. NandN Scientific, Inc. (NandN) is developing a first of its class broad-spectrum orally bioavailable antiviral drug, N- methanocarbathymidine (N-MCT), which has exhibit ...

    SBIR Phase II 2012 Department of Health and Human Services
  7. Development of Small Molecules as Antiprotozoal Agents

    SBC: RADIX PHARMACEUTICALS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The proposed research focuses on the development of novel therapeutic agents for the prevention and treatment of malaria caused by P. falciparum. A previous Phase I project has discovered novel molecules with potent antimalarial activity against both sensitive and multidrug resistant malaria strains in some in vitro and in vivo models. Lead compounds are low in ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Device to Improve Treatment of Colorectal CA using O2 Dependent Phosphorescence

    SBC: SURGISENSE CORPORATION            Topic: NCI

    DESCRIPTION (provided by applicant): Standard of care for surgical resection of rectal cancer is the performance of low anterior resection (LAR). After removal of the cancerous segment, a surgical stapler is used to restore continuity by creating an anastomosis between the resulting ends of disjointed bowel. Anastomotic leak is one of the most dreaded complications of colorectal surgery due to the ...

    SBIR Phase II 2012 Department of Health and Human Services
  9. A Tool for Supporting and Monitoring Decision Making in ADHD

    SBC: Total Child Health, Inc.            Topic: NIMH

    DESCRIPTION (provided by applicant): This proposal is to complete and validate a new web-based tool to assist in the screening, diagnosis and management of mental health disorders (focusing here on ADHD), quality improvement (QI) documentation and efficient large scale research. CHADIS is a screening, assessment and decision support system delivering tools online for care of health, development, a ...

    SBIR Phase II 2012 Department of Health and Human Services
  10. IGF::OT::IGF OTHER FUNCTIONS DEVELOPMENT OF TOOLS FOR CRYOGENIC BIOPSY OF SOFT TISSUE.

    SBC: Robin Medical, Inc.            Topic: NCI

    Molecular medicine holds promise for advancing cancer diagnosis and treatment if biomarkers can be accurately assessed in tumors. The objective of the project is to develop and test a new biopsy system that stabilizes the target tissue and prevents changes in biomarker levels due to ischemia in the excised tissue sample. The specific aims of the project are: 1. Design and build a clinic-ready, ...

    SBIR Phase II 2012 Department of Health and Human Services

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