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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Whole-brain fluorescence and brightfield imaging at single-cell level

    SBC: DMetrix, Inc            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop an open and flexible imaging platform capable of rapid, 0.5- 5 m pixel resolution image capture of large-area histology sections (up to 125 mm by 175 mm), in brightfield and by epi-fluorescence optical sectioning. The project involves state-of-the- art instrumentation development coupled with application programming inter ...

    SBIR Phase II 2012 Department of Health and Human Services
  2. NOVEL HIGH THROUGHPUT PLATFORM FOR SCREENING CYTOCHROME P450 INDUCTION

    SBC: ORIGINUS, INC.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Many prescribed drugs exhibit drug-drug interactions due to up-regulation or inhibition of specific P450 enzymes. According to a recent guidance from the FDA, CYP1A2, CYP2B6, and CYP3A4 induction should be evaluated inat least an in vitro system. Enzymatic activity in freshly isolated hepatocytes is the Gold Standard for studying P450 induction; however, it ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. An Antisense Design and Simulation Platform

    SBC: DNA SOFTWARE, INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): In this grant proposal An Automated Antisense Design and Simulation Platform , a comprehensive molecular diagnostics software tool that is specific to the design and simulation of antisense oligonucleotide analog probes will be developed. The application of antisense technologies to the study of human diseases has been proven in the literature for cancer, im ...

    SBIR Phase II 2012 Department of Health and Human Services
  4. Novel Micro-Implant to Measure Intracardiac Pressure in Congenital Heart Patients

    SBC: Integrated Sensing Systems Incorporated            Topic: NHLBI

    DESCRIPTION (provided by applicant): Congenital heart disease patients with functional single ventricle (FSV) anatomy usually require a series of surgeries during infancy and childhood in order to provide them with a chance to survive into adulthood. The second stage surgery, termed the hemi-Fontan procedure (HFP) re-routes systemic venous blood from the upper body and head into the pulmonary circ ...

    SBIR Phase II 2012 Department of Health and Human Services
  5. Selective Cytopheresis Therapy in Systemic Inflammatory Response Syndrome

    SBC: Innovative Biotherapies, Inc.            Topic: NCATS

    DESCRIPTION (provided by applicant): Leukocytes (LE) are major contributors to the pathogenesis and progression of many clinical inflammatory disorders, including the systemic inflammatory response syndrome, sepsis and acute respiratory distress syndrome.The need for new and innovative therapies to treat these inflammatory disease states presents a large commercial market opportunity. A large numb ...

    SBIR Phase II 2012 Department of Health and Human Services
  6. Ionomer-membrane Water Processor System Design and EDU Demonstration

    SBC: Paragon Space Development Corporation            Topic: X301

    a. Paragon Space Development Corporation¿ (Paragon) proposes to continue our investigation into the use of microporous-ionomer membrane technology to improve the robustness and effectiveness and simplify water recovery processes for space applications. Improved robustness and effectiveness will be evident through (1) reduced loading onthe downstream post processor due to the ionomer¿s unique pr ...

    SBIR Phase II 2012 National Aeronautics and Space Administration
  7. Frequency-Locked Single-Frequency Fiber Laser at 2 Micron

    SBC: AdValue Photonics Inc            Topic: S101

    Frequency-locked single-frequency 2 micron fiber laser is proposed to be used for airborne/spaceborne coherent lidar measurements, i.e., Active Sensing of CO2 Emissions over Nights, Days, and Seasons. The laser is based on our proprietary fiber technology and extensive experience in fiber laser development, which features a compact, highly stable, frequency-stabilized light source. Advanced freque ...

    SBIR Phase II 2012 National Aeronautics and Space Administration
  8. Miniaturized Time Domain Terahertz Non Destructive Evaluation for In-Orbit Inspection of Inflatable Habitats and Thermal Protection Systems

    SBC: PICOMETRIX, LLC            Topic: X504

    Picometrix's time-domain terahertz (TD-THz) non-destructive evaluation (NDE) technology could be used to inspect space flight structures such as inflatable space habitats, thermal protection systems (TUFI-type tiles, SOFI TPS), for voids, disbonds, and damage such as tearing and micron-meteorite impact. The current instrumentation paradigm is that a multi-purpose TD-THz control unit is used ...

    SBIR Phase II 2012 National Aeronautics and Space Administration
  9. Multispectral Desert Fauna Surveillance and Recognition System

    SBC: Cybernet Systems Corporation            Topic: AF093222

    ABSTRACT: In Phase I, Cybernet worked with the Air Force to design and create an automated monitoring system for gathering census data about potentially endangered species to assist with compliance with the Sikes act. This Animal Detection Module (ADM) features visible and infrared cameras, a relational database for stored still pictures, video, and metadata, and Cybernet"s cutting edge image pr ...

    SBIR Phase II 2012 Department of DefenseAir Force
  10. Non-Intrusive Direct Part Marking with Femtosecond Laser Pulses

    SBC: Physics, Materials, and Applied Mathematics Research L.L.C.            Topic: AF093191

    ABSTRACT: In Phase I, we presented options for direct marking of high-performance turbine parts using ultrashort pulse lasers, that do not compromise the integrity of said parts. In the proposed effort, we will work with our customer to: evaluate metallurgy and fatigue, and mark quality on the range of materials used for fracture critical parts; develop marking conditions for all major alloys to ...

    SBIR Phase II 2012 Department of DefenseAir Force

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