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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. An Integrated Microarray Printing and Detection System

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. SBIR Phase II: Quasi-Active Prosthetic Ankle System: Dynamic Angle and Stiffness Optimizations for Multiple Gait Activities

    SBC: Springactive, Inc.            Topic: EW

    The broader impact/commercial potential of this project is that the proposed system will enhance the ability of the 1.3 million people currently living in the United States with a lower limb amputation to walk in unconstrained environments. The proposed Quasi-Active Prosthetic Ankle System (QPAS) addresses the RH6: Human Assistive Technologies area. QPAS will be lightweight, have a long battery li ...

    SBIR Phase II 2017 National Science Foundation
  4. Tools for Accelerating R&D for Historically Understudied Protein Kinases

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: NCATS

    Protein kinases are central players in almost every aspect of human physiology and serve as critical mediators of signal transductionThe dysfunction of many kinases is implicated in cancerdiabetesinflammationand cardiovascular diseases and many are validated targets for therapeutic interventionThe human genome encodesprotein kinasesYettheor so marketed protein kinase drugstarget only a small fract ...

    SBIR Phase II 2017 Department of Health and Human Services
  5. Solar-Powered High-Efficiency CO2 Refrigeration Technologies

    SBC: SUNDANZER DEVELOPMENT INCORPORATED            Topic: NonDoD

    SunDanzers High efficiency Refrigeration Unit (HERU) technology is a variable speed, two stage refrigeration platform, initially developed under Army SBIR topic A04-210, and continuing with Army Rapid Innovation Funding. HERU currently uses the military standard hydrofluorocarbon R-134a, vehicle type refrigerant. R-134a leaking into the atmosphere has 1400 times the greenhouse gas effect compared ...

    SBIR Phase II 2017 Department of DefenseArmy
  6. Preclinical development of PPCM vaginal contraceptive to submit IND.

    SBC: YASO THERAPEUTICS INCORPORATED            Topic: NICHD

    PROJECT SUMMARYThe goal of this project is to develop a novel vaginal contraceptive gel product containing PPCM sodium saltPPCMPPCM is a novel polymer drug that inhibits infection of HSVHIVNgonorrhea and is also contraceptiveThis novel drug has an average molecular weight ofis designed to be used topicallyand thus far passed all safety studies and does not appear to be systemically absorbedPPCM ha ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. Surface Metrology fro X-ray Mirrors using Deflectometry

    SBC: ARIZONA OPTICAL SYSTEMS, LLC            Topic: 04c

    Arizona Optical Systems is developing a measurement technique that enables production of higher accuracy x-ray mirrors for DOE lightsource facilities. Mirror defects, which are too small to measure using existing techniques, degrade beamline performance. Higher accuracy x-ray mirrors increase the energy density of existing sources without requiring new, larger facilities.

    SBIR Phase II 2017 Department of Energy
  8. 21st Century Grid Management- Advanced Big Data Analysis

    SBC: PRIME SOLUTIONS GROUP, INCORPORATED            Topic: 01c

    This project addresses the need for technologies to help electric utility companies evolve toward, and meet the emerging challenges of, the Smart Grid of the future. These tools will help manage and utilize Big Data from the distribution system to facilitate the planning, control, and security of tomorrow’s electric distribution system.

    SBIR Phase II 2017 Department of Energy
  9. Development of New Improved Perflutren Ultrasound Contrast Agent

    SBC: MICROVASCULAR THERAPEUTICS LLC            Topic: NHLBI

    Three ultrasound contrast agents Definity Optison and Lumason are FDA approved for echocardiography in the U S Definity currently has over market share Definity s dominance in the market is due to its ease of administration via IV infusion and robust ultrasound contrast Definity has shelf life of years and must be stored under refrigerated conditions Definity has an unpleasant ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Radiation-Hard DC-DC Converter

    SBC: Alphacore, Inc.            Topic: 28h

    The upgrade of the physics experiments for the High Luminosity LHC (HL-LHC) at CERN is currently driving the development of new and more efficient powering schemes to cope with the increase of power demanded by the new high-density front-end electronics boards. Due to the high radiation levels of up to hundreds of Mrad at the HL-LHC, commercial DC-DC converters cannot be used in these powering sc ...

    SBIR Phase II 2017 Department of Energy

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