Award Data

C53-02a-271164Research and development advances in novel nuclear reactor design for power production depend on computer simulations to validate efficiency and safety. Most existing simulation co des require training and expertise and have restrictive licenses that make them hard to acquire and use. One promising open-source code is easy to use and can spread its calculations across many computers, ...

C53-12a-271184Photocathodes are critical for generation of high-brightness electron beams in accelerators that are used in science, industry, and medical disciplines. A visible wavelength-tunable picoseconds laser is required to support optimization of photocathodes leading to more compact, high-performance, and cost-effective systems. Such lasers are not available commercially. With new sources o ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project begins with a wearable, non-invasive device providing vital brain and internal organ temperature measurements in a clinical setting that can dramatically reduce mortality and the risk of permanent brain damage for tens of thousands of patients experiencing cardiac and aortic repair surgery. T ...

The broader impact/commercial potential of this Small Business Innovation Research Phase II project is to develop a mature, market-ready approach for building targeted, readily synthesizable inhibitors of viral proteases. The technology will extend the discovery platform to new targets and disease indications and build a biochemical foundation for progressing preclinical programs to promising lead ...

This Small Business Innovation Research (SBIR) Phase II project produces compact optical frequency standards using state-of-the-art optical frequency metrology techniques adopted from national metrology institutes. Commercially, these devices will produce fundamentally accurate and stable optical frequencies in the form of laser light. End uses of these optical frequency standards include telecomm ...

The broader impact of this Small Business Innovation Research (SBIR) Phase II project stems from its potential to treat arthritis in joints. This research will be the first investigation into the use of liquid-crystal elastomers (LCEs) for joint repair to treat hallux rigidus. Hallux rigidus (HR) is a joint disorder at the base of the big toe affecting approximately 2.5% of people over 50 years ol ...

ProjectSummary Lackofavailabilityofreliabledistributedcoldstorageco-locatedwithfoodproductionand distributionposeslimitationsforlocalfoodsupplychainsforfarmersandmarketers.Radiant InnovationLLC(Radiant)seekstoaddressthedemandforclimatefriendlyoff-gridcoldstorage andincollaborationwithColoradoStateUniversity(CSU)proposestocalibrateanddeployour model-predictive-controlstrategywithfoodquality/safetya ...

XUV Lasers, in collaboration with Colorado State University, proposes to develop and commercialize key components for the implementation of ultra-intense laser systems operating at greatly increased repetition rates. Ultra-high power, ultrashort pulse lasers systems are the central tool driving many of the recent advances in high energy density plasma science. They enable the generation of high en ...

Internet-based TRAC (i-TRAC): Interactive Emotion Regulation Skills Training to Improve AdolescentSexual Health Adolescence is a critical developmental period during which behavioral patterns are formed that have powerful influences on current and future health. This is particularly true for sexual behavior, which is affected by the biological changes of puberty as well as normative developmental ...

Abstract Cutaneous T-cell lymphoma (CTCL) is a type of extra-nodal non-Hodgkin’s lymphoma characterized by skinlesions resulting from infiltration of malignant T lymphocytes. Mycosis fungoides and Sezary syndrome are thetwo most common types of CTCL. Although treatments exist, they are mainly palliative with low response anddurability of response without any cure. The objective response rate rem ...