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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Advanced Solutions for Radiation Susceptibility Analysis & Prediction

    SBC: LUCID CIRCUIT, INC.            Topic: DTRA162006

    With the advent of high-density low-power sub-20nm technology processes and circuits with tens-of-billions of transistors, radiation-induced single-event effects present a new set of design challenges for terrestrial applications. Developing reliable single-event effect resilient microelectronics in these modern technology nodes is a resource and time-intensive endeavor that further requires valid ...

    SBIR Phase II 2019 Department of DefenseDefense Threat Reduction Agency
  2. Story Mode for Teaching Cross-Curricular Coding Projects

    SBC: CODESPARK, INC.            Topic: 91990019R0012

    In previous R&D, the developers created codeSpark Academy, a game that employs a visual and block-based approach with puzzles to teach coding skills to students ages 5 to 9 years old. codeSpark Academy is in widespread use in and out of schools around the world. In this project, the developers will expand storytelling creative tools within the existing game. The pretend-play scenarios will include ...

    SBIR Phase II 2019 Department of EducationInstitute of Education Sciences
  3. Rapid diagnostic to determine CMV serological status

    SBC: NANOCOMPOSIX INC            Topic: NIAID

    The goal of this project is to develop a diagnostic that can support the enrollment of seronegative individuals in clinical trials of candidate cytomegalovirusCMVvaccinesCongenital CMV infection is one of the leading causes of non genetic birth defects worldwideIf a successful vaccine can be brought to marketit will have a significant impact on the number of babies born with hearing and vision los ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of a Benchtop Laboratory Platform for Amplicon Deep Sequencing

    SBC: Trace-Ability, Inc.            Topic: ODCDC

    The aim of this Phase II proposal is to deliver a functional prototype of a Benchtop Laboratory Platform for Amplicon Deep SequencingLong term objective is to turn this prototype into a standardizing platform for sequencing laboratoriessuch as those participating in GHOST programAvailability of a compact machineaffordable for the majority of laboratories with lowto medium throughput sequencing nee ...

    SBIR Phase II 2019 Department of Health and Human Services
  5. TOPIC 359: A DEVICE PROTOTYPE FOR ISOLATION OF MELANOMA EXOSOMES FOR DIAGNOSTICS AND TREATMENT MONITORING

    SBC: Aethlon Medical, Inc.            Topic: NCI

    The proposed work aims to develop a pre commercial prototype of an exosome isolation device to be used in clinical diagnostic laboratoriesWe will advance the device to facilitate exosome isolation for downstream liquid biopsy tests requiring analysis of proteinDNAor microRNAwhich rely upon acquisition of intact and pure exosomesThe device strategy will be designed to isolate total exosomes and the ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. TOPIC 360: A SIMPLE END-TO-END SYSTEM FOR SERIAL CELL SORTING AND MANIPULATION USING A SINGLE CONTAINER- MOONSHOT

    SBC: DIAGNOLOGIX, LLC            Topic: NCI

    Chemotherapy may control but rarely cure metastatic cancersRemarkablymodern immunotherapiesincluding cell based therapieshave cured metastatic melanomas and other types of cancersA major challenge for all cell therapies in general is the need to develop cost effective and efficient manufacturing and delivery capabilitiesWe have recently established an innovative cell isolation technology by applyi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. TOPIC 353: HIGHLY ACCURATE LOW COST CTDNA DIAGNOSTICS WITH MAGNETIC NANOPARTICLE ENABLED AUTOMATED SAMPLE PREP- MOONSHOT

    SBC: NVIGEN            Topic: NCI

    The goal of the research is to develop a highly accurateautomatedand low cost ctDNA test to monitor efficacy of treatment of metastatic breast cancer patients by identifying the emergence of certain DNA mutations in plasma samplesThere is growing evidence that the presence of certain DNA mutations in the blood stream correlates with breast cancer becoming resistance to hormone treatmentNVIGEN will ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. IGF::OT::IGF TOPIC 372 DEVELOPMENT AND VALIDATION OF NON-MOUSE REAGENTS TO ENABLE PRECLINICAL DEVELOPMENT OF NOVEL THERAPEUTICS- MOONSHOT

    SBC: SYNBAL, INC.            Topic: NCI

    In this Fast track SBIR grant we aimby the end of Phase IIto prepare and commercialize a fully humanized rat with Knock out of many rat drug metabolism related CYPsinout Rat Drug Metabolism CYPModeland Knock in of the human counterpartIN PHASE I we will develop an Active GenesGene DriveAG GDrata rat with a properly configured Casto power Active GeneticsAGANDwe will prepare the first CYPKout KinCYP ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. CANNABIS IMPAIRMENT DETECTION APPLICATION (CIDA) (T163). SBIR PHASE II. POP: 9/20/2019-9/19/2021. N44DA-19-1218.

    SBC: ADVANCED BRAIN MONITORING, INC.            Topic: NIDA

    Under this Small Business Innovation ResearchSBIRPhase I projectResearch Topicthe Contractor will develop a portableeasily applied system incorporating a neuropsychological test protocol to detect cannabis impairment

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Improving Spatiotemporal Precision in Noninvasive Electrical Neuromodulation

    SBC: Brain Electrophysiology Laboratory Company, LLC            Topic: 101

    This application describes the commercialization of the Geodesic Transcranial Electrical NeuromodulationGTENtechnology to achieve noninvasive neuromodulation with improved spatiotemporal precisionThe GTEN system enables both EEG source analysis and configurable electrical neuromodulation with theelectrodes of the Geodesic Sensor NetNow in beta release to selected research customersthe GTEN technol ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health

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