Award Data

THE GOAL OF THE PROPOSED RESEARCH IS TO PROVIDE THE NUCLEAR MEDICINE COMMUNITY WITH A COMPACT LINEAR ACCELERATOR (LINAC) FOR THE PRODUCTION OF THE PRINCIPAL SHORT-LIVED RADIOISOTOPES USED IN POSITRON EMISSION TOMOGRAPHY. THE DESIGN OF THIS LINAC WILL BE BASED ON EXCITING NEW TECHNOLOGIES DEVELOPED FOR A PION-GENERATING LINAC (PIGMI) AT THE LOS ALAMOS NATIONAL LABORATORY AND FUNDED BY THE NATIONAL ...

THE LONG-TERM OBJECTIVE OF THE PROPOSED PROGRAM IS TO DEVELOP A CONTROLLED-RELEASE DISULFIRAM IMPLANT FOR USE IN THE TREATMENT OF ALCOHOLISM. SPECIFIC PHASE I GOALS ARE 1. TO DESIGN CANDIDATE SYSTEMS, BASED ON TARGET PERFORMANCE TO BE DETERMINED FROM A REVIEW OF PRIOR RESEARCH, 2. TO PREPARE A SERIES OF CANDIDATE SYSTEMS, AND 3. TO DETERMINE THE IN VITRO DRUG RELEASE FROM THESE CANDIDATES. THE PRO ...

AS MORE AND MORE INDIVIDUAL LONG-TERM CARE INSURANCE POLICIES ARE BEING MARKETED TO ELDERLY AND PRE-RETIREES, THE MEDICARE-ELIGIBLE CONSUMER IS FACED WITH A DIFFICULT TASK IN SELECTING THE POLICY THAT BEST MEETS HIS OR HER NEEDS. PHASE I OF THIS PROJECT IS DEVOTED TO A SURVEY OF THESE POLICIES, STATE REGULATIONS AFFECTING INSURANCE PRODUCTS, AND STATE MEDICAID ELIGIBILITY CRITERIA. FROM THESE DATA ...

THE LONG-TERM OBJECTIVE OF THIS PROPOSAL IS TO DEVELOP AND IMPLEMENT STATE-OF-THE-ART COMPUTER SIMULATION SOFTWARE TECHNIQUES INCLUDING MOLECULAR DYNAMICS, MOLECULAR MECHANICS, NORMAL MODE ANALYSIS, AND INTERACTIVE GRAPHICS ANALYSIS INTO AN INTEGRATED SYSTEM TO ATTACK PROBLEMS IN PROTEIN DESIGN. THE ABILITY TO UNDERSTAND, GUIDE, AND ACCURATELY SIMULATE THE EFFECTS OF MODERN RECOMBINANT DNA TECHNIQ ...

THIS PROPOSAL DESCRIBES THE DEVELOPMENT OF A MODERN DIAGNOSTIC TEST AND THERAPY FOR INFANT RESPIRATORY DISTRESS SYNDROME (RDS). RDS IS THE LEADING CAUSE OF NEONATE MORTALITY AND MORBIDITY. IT IS DUE TO INADEQUATE LEVELS OF LUNG SURFACTANT, A LIPID-PROTEIN COMPLEX ESSENTIAL FOR LUNG INFLATION. CURRENT DIAGNOSTIC ASSAYS ARE BASED ON THE LIPID COMPONENT OF SURFACTANT AND ARE UNRELIABLE. WE PROPOSE TO ...

HYPERTENSION IS A SERIOUS AND WIDESPREAD MEDICAL PROBLEM. WHILE A VARIETY OF APPROACHES CURRENTLY EXIST FOR CONTROLLING HYPERTENSION, MANY PATIENTS COULD BENEFIT FROM NEW ANTIHYPERTENSIVE DRUGS THAT ARE MORE SPECIFIC THAN THOSE PRESENTLY AVAILABLE. RENIN INHIBITORS CONSTITUTE A POTENTIAL CLASS OF HIGHLY ACTIVE YET SPECIFIC ANTIHYPERTENSIVE AGENTS. ONE IMPEDIMENT TO THE DESIGN OF USEFUL RENIN INHIB ...

INFLAMMATORY DISORDERS ACCOUNT FOR A SIGNIFICANT PERCENTAGE OF DEBILITATING DISEASES. IT IS NOW APPARENT THAT CENTRAL TO THE THERAPEUTIC CONTROL OF THE INFLAMMATORY REACTION IS THE REGULATION OF THE PHOSPHOLIPID METABOLITES, THE EICOSANOIDS. IN MOST TISSUES THE SYNTHESIS OF THE EICOSANOIDS IS LIMITED BY THE AVAILABILITY OF ARACHIDONIC ACID (AA) WHICH IS FIRST LIBERATED FROM MEMBRANE PHOSPHOLIPIDS ...

FOR HIGH-ENERGY NICKEL-ZINC BATTERIES A NEW HIGH-ENERGY NICKEL-ZINC RECHARGEABLE BATTERY SYSTEM FOR APPLICATION IN VENTRICULAR ASSIST SYSTEMS (VAS) IS PROPOSED. THE PARTICULAR R&D ASPECT OF THE PROPOSED PHASE I PROGRAM IS THE STUDY OF A NEW APPROACH TOWARDS A HIGH-CAPACITY NICKEL ELECTRODE EMPLOYING A LIGHTWEIGHT CARBON COMPOSITE MATRIX AND, THEREFORE, LEADING ALSO TOWARDS HIGHER ENERGY DENSITIES. ...

THE MEMBERS OF THE DEAF COMMUNITY IN THE UNITED STATES ARE ISOLATED FROM BOTH THE HEARING POPULATION AND EACH OTHER. A PRIMARY CAUSE OF THIS ISOLATION IS THE ABSENCE OF A COMMONLY ACCEPTED WRITTEN FORM OF AMERICAN SIGN LANGUAGE (ASL). A RECENTLY DEVISED SYMBOL SET, CALLED SIGN WRITING (R), HAS BEEN WELL RECEIVED, YET ITS DISSEMINATION HAS BEEN LIMITED BY THE NEED TO PRODUCE THE SYMBOLS BY HAND. TH ...

EACH YEAR THERE ARE 70,000 NEW HEAD TRAUMA VICTIMS WHOSE PRIMARY MEDICAL AND LONG-TERM REHABILITATION COSTS PLACE TREMENDOUS FINANCIAL BURDENS ON THEIR FAMILIES. THE NEED IS GREAT FOR LOW-COST REHABILITATION TOOLS THAT CAN BE USED IN THE HOME TO SUPPLEMENT AND PHASE I OF THIS EFFORT WILL EXPLORE THE VIABILITY OF COMPUTER SOFTWARE IMPLEMENTED ON APPLE COMPUTERS. FIVE SAMPLE MODULES THAT TEACH SOME ...