Award Data

Project Summary As a participant in the new IDeA Regional Entrepreneurship Development (I-RED) program, the goal of this proposal is to create an educational product to promote entrepreneurism and commercialization in the Mountain West region of IDeA states. The educational product and overall program are intended to address the needs of IDeA state academic institutions in developing and strengthe ...

PROJECT SUMMARY In this Phase II SBIR, HomesRenewed Ventures, LLC (HRV Washington, DC) will build on our previous efforts to expand and validate an interactive mobile application (APP) for guiding home modifications (environmental interventions) critical to Aging in Place (AiP). Home modifications (HM) are associated with falls preventions, improved activities of daily living (ADLs), and emotional ...

Project Summary/Abstract The proposed effort addresses the need for novel therapeutic tools that improve chronic wound healing outcome. Recent studies show that patients with diabetic foot ulcers have a 40% recurrence rate within 1 year after treatment and healing, nearly 60% within 3 years, and 65% within 5 years, while the 5-year mortality rate is exceeded only by lung cancer. Lower limb wounds ...

Project SummaryLung cancer (LC) with over 2 million cases/year worldwide also remains the leading cause of cancer- related death in the US and Europe. Treating LC remains challenging due to ~60% of patients presenting with Stage IV disease, the heterogeneity of tumors with respect to genetic and epigenetic mechanisms that alter gene expression, and treatment-related resistance. Combining chemother ...

Project Summary: The field of quantitative biology involves using mathematics, statistics, and modeling to analyze the results of biological experiments. Students at the high school and undergraduate levels can develop these skills through a comprehensive STEM (science, technology, engineering, and math) education. These analytical skills are crucial for success in many careers, including those in ...

There is a growing need to accurately characterize nuclear materials not only for nuclear safeguards and nonproliferation treaty verification but also for forensics and provenance. At present, nuclear material identification requires samples to be collected and sent to laboratories for analysis using large and expensive equipment, such as inductively coupled plasma mass spectrometers (ICP-MS) or s ...

This proposal for Phase II in response to the Defense Threat Reduction Agency (DTRA) topic 212-006 “Algorithm that can locally link radiation detectors (of different resolutions) to enhance identification/ localization capability”. The topic describes the need for an algorithm to support the fusion of multiple and varied detector outputs into actionable information. The specific focus is to id ...

Abstract Project Summary Applikate Technologies has developed Clearing Histology with Multiphoton Microscopy (CHiMP), a novel tissue processing and imaging platform that provides direct-to-digital images from intact pathology tissue specimens, such as biopsies, without the need for wax embedding, slicing, or scanning of slides. The application of this technology to cancer diagnosis will reduce err ...

Project Summary Skin is the first line of defense against the outside environment. When the skin barrier is breached by UV irradiation (UVR) or toxic chemicals, living cell layers including epidermal keratinocytes, melanocytes and dermal fibroblasts are subjected to DNA damage. If unrepaired, this damage can lead to photoaging and cutaneous carcinogenesis. In fact, skin cancer is by far the most c ...

The long-range goal of this fast-track research application is to improve healthcare quality and reduce healthcare costs nationwide among those at risk for medication-related hospitalization. The specific objective of this proposed research is to develop an algorithm that uses existing electronic health information to efficiently identify patients at risk of medication-related hospitalization so t ...