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Project SummaryPositron Emission TomographyPETis regarded as a standard of care in the management of multiple types of cancerAvailability of this procedure relies on a steady supply of a radioactive contrast agentFFluorodeoxy d glucoseFDGDue to the inherent short half lifeminmultiple batches of FDG are typically produced at multiple sites on daily basisQuality ControlQCof FDG remains the most labo ...

PROJECT SUMMARY ABSTRACTOur goal in this SBIR effort is to produce a web based suite of tools and services to help researchers design methodologically sound experiments for improved research outcomes and reproducibility of resultsDesignAssist provides a promising approach that connects animal researchers to experimental design expertisedelivering a cost effective solutionalleviating the need for i ...

Project SummaryFlow cytometry is an indispensable tool for interrogating the immune system in researchdrug discovery and diagnostic applicationsThe platform has undergone tremendous expansion over the past decade and nowmodern cytometers are able to analyzetoparameters per single cellfor millions of cells per sampleand hundreds of samples per experimentHoweveras the number of parameterssamplesand ...

Abstract The Flavivirusesespecially DengueZika and Yellow Fever have been a major public health concern for centuries in semi and tropical climatesincluding parts of the southern USPresentlythese viruses are the cause of more thanmillion infections per yearGlobal travelalteration of the underlying mosquito vector s geographical rangethe possibility of RNA genome mutation resulting from vector chan ...

Abstract Neisseria gonorrhoeaeGCis the second most common cause of bacterial sexually transmitted diseasesSTDwith an estimated world prevalence ofmillionApproximatelycases occur annually in the U Sbut over half are unreportedand rates continue to rise as indicated by aincrease fromtoGC is a major cause of pelvic inflammatory diseasePIDthat can lead to tubal factor infertilityectopic pregnancy and ...

SignificanceRobotic radiotherapy using extensively non coplanar beams has been shown effective to significantly improve radiation therapy dosimetryleading to improved treatment outcomesHoweverthe current implementation of this technique by CyberKnife is inefficient and not dosimetrically optimalThis has severely limited both the number of patients eligible for robotic radiotherapy and the achievab ...

Project Summary Drug combination therapy has revolutionized cancer treatment and is now the mainstay of most modern regimensIn spite of the successit is evident that in most casesthe cancer either does not respond to the initial treatment or a form of the cancer emerges that is cross resistant to multiple drugsInvestigation into the molecular causes of cancer and dramatic improvements to the drug ...

Project summaryThe oxidative capacity of airborne particulate matter has been correlated with the generation of oxidative stress both in vitro and in vivoIn recent yearsepidemiological studies have associated damaged caused by cellular oxidative stress with several common diseases such as asthmachronic obstructive pulmonary diseaseCOPDAlzheimer s and other neurological diseasesEven though recent s ...

ABSTRACT Sinceseveral nitrogen containing bisphosphonateNBPdrugs have been approved for the treatment of Pagetandapos s diseasemetastatic disease of the boneand osteoporosisThe later indication has led to the prescription of these drugs to millions of patients in the lastyearsPatients who have bone metastasis receive very large doses of these drugsin some cases receiving the amount in one month th ...

Project Summary Abstract ErythroferroneERFEthe erythroid regulator of hepcidin has recently been discovered and characterized as a hormone expressed in erythroblasts in the marrowERFE responds to erythropoietinEPOsignaling from the EPO receptors in the marrow that stimulate ERFE synthesis and release into the plasmaERFE then acts as a suppressor of hepcidin expression in the liverHepcidin is the m ...