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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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HBI-002 to Prevent Vaso-Occlusive Crises in Sickle Cell Disease
SBC: Hillhurst Biopharmaceuticals, Inc. Topic: NHLBIPROJECT SUMMARY/ABSTRACT The goal of the proposed project is to evaluate the clinical potential of HBI-002, a novel oral low dose carbon monoxide (CO) drug product, that enables the use of low dose CO to prevent Vaso-Occlusive Crises (VOCs) in Sickle Cell Disease (SCD). Numerous studies, both preclinical and clinical, demonstrate that CO has dual mechanisms of action including anti-sickling and an ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
A silicon nanopore membrane blood filter enabling anticoagulant free continuous renal replacement therapy for acute kidney injury
SBC: Silicon Kidney Topic: 400Project Summary Acute Kidney Injury (AKI) commonly occurs in critically ill patients in the ICU. Patients with severe AKI often require continuous renal replacement therapy (CRRT) because it enables hemodynamic stability and better volume control. Anticoagulation therapy is frequently used to keep the CRRT circuit (especially the blood filter) from clotting as many critically ill patients are prot ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Novel peptide for enhancing diabetic wound healing
SBC: SCARLESS LABORATORIES INC Topic: 200PROJECT SUMMARY/ABSTRACT Diabetes Mellitus (DM), a metabolic disorder characterized by defective insulin signaling and elevated blood glucose, has become a public health epidemic with half of the US population diagnosed with either DM or pre- diabetes. One of the most common and devastating sequelae of uncontrolled DM is the development of chronic non-healing wounds. An estimated 25% of diabetic p ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Development of a SYF2 antisense oligonucleotide treatment for ALS and FTD
SBC: ACURASTEM INC Topic: NIADevelopment of a SYF2 antisense oligonucleotide treatment for ALS and FTD Project Summary Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are complex diseases that result from many diverse genetic etiologies. Although therapeutic strategies that target specific causal mutations (e.g. C9ORF72 antisense oligonucleotides (ASOs)) may prove effective against individual forms of AL ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Humanized monoclonal antibodies to treat mucormycosis
SBC: VITALEX BIOSCIENCES, LLC Topic: NIAIDMucormycosis, caused by Mucorales fungi, is a life-threatening infection that occurs in patients immunocom- promised by diabetic ketoacidosis, neutropenia, corticosteroid use, and/or increased serum iron. Because of the rising prevalence of mucormycosis risk factors, the incidence of the infection has risen. The increased number of mucormycosis cases is highlighted by the recent epidemic seen amon ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Novel Post-surgical Incision Management Device to Prevent Ostomy Complications
SBC: FISTULA SOLUTION CORPORATION Topic: 102Project Summary/Abstract Over 100,000 patients of all ages undergo ostomy surgery in the United States (US) annually due to a variety of pathophysiologic conditions including colorectal cancer, inflammatory bowel disease (Crohn’s disease and ulcerative colitis), bowel obstruction, diverticulitis, and many other medical conditions. Ostomy surgery may also be necessary in cases of severe abdominal ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Selective actin remodeling of sensory neurons for acute pain management
SBC: Neurocarrus Inc. Topic: 106PROJECT SUMMARY There is an urgent need for new approaches to treat acute human pain without the risk of Substance Use Disorders (SUDs). The most effective approved pain pharmaceuticals, including narcotics and anesthetics, are not neuron-specific and consequently suffer from off-target effects like addiction, inhibition of motor neurons, and destruction of the surrounding tissues. When inflammati ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Preclinical development of ONCT-505, an Androgen Receptor Antagonist and Degrader, as new potential therapeutic for Kennedy's Disease
SBC: ONCTERNAL THERAPEUTICS, INC. Topic: 106PROJECT SUMMARY Kennedy’s disease, also known as spinobulbar muscular atrophy (SBMA), is a progressive neurodegenerative disease caused by genetic polyglutamine expansion in the N-terminal domain (NTD) of the androgen receptor (AR). Recent research has shown that the mutant AR protein misfolds, aggregates, and abnormally interacts with other proteins, leading to androgen- dependent lower motor n ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Development of a high precision and high order DNA counting platform
SBC: ENUMERIX, INC. Topic: 400PROJECT SUMMARY/ABSTRACT Enumerix has developed a cost-effective method to perform high order DNA counting at high precision called direct count PCR (dcPCR). dcPCR uses a spin column method that generates millions of partitions directly into PCR tubes for target amplification, using standard laboratory centrifuge and thermal cyclers, followed by an ultra-rapid method to count up to 1 million copie ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
Phase IIB Plasticity-based Adaptive Cognitive Remediation for Alzheimers Disease
SBC: POSIT SCIENCE CORP Topic: NIAProject Summary Abstract The primary objectives of the current project are 1) to evaluate the longer-term efficacy of PACR-AD cognitive training (PACR-CT) measured 5 years after the completion of initial 10 weeks of training, 2) to determine the efficacy of the 10 weeks of booster training after 5 years from the initial training completion, and 3) to redesign the PACR-CT for optimal training sched ...
SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health