Award Data

The GHz-rate phase-stabilized fiber-laser frequency comb system is proposed to be used as a light source for coherent Fourier transform spectroscopy. The system will be developed based on our proprietary glass/fiber technology, which features a low-cost, robust, highly stable, mid-infrared light source that enables the development of a robust portable c-FTIR spectrometer for absorption measurement ...

DESCRIPTION (provided by applicant): The detection and enumeration of circulating tumor cells (CTCs) has the potential to become a very powerful tool in cancer diagnosis and treatment. However, current technologies for CTC detection are not yet established in routine clinical practice. One reason is that CTCs are present in blood at an extremely low concentration of one in 10 million white blood c ...

DESCRIPTION (provided by applicant): We have developed an effective bacterial cancer therapy strategy by targeting viable tumor tissue by using Salmonella typhimurium auxotrophs that we have generated which grow in viable as well as necrotic areas of tumors. However, the auxotrophy severely restricts growth of these bacteria in normal tissue enabling them to be used for cancer treatment. The S. ty ...

DESCRIPTION (provided by applicant): The aim of this project is to develop and optimize our novel particle-based microarray platform, ArrayableESP, for application to high multiplex (50- to 2000-plex) proteomic analysis of human serum samples. ESPs are optically-encoded microfabricated particles that can be manipulated using magnetic force. They are manufactured on commercially available photolith ...

DESCRIPTION (provided by applicant): The long-term goal of this research is to minimize morbidity due to non-adherence to outpatient antipsychotic-antimanic therapy with olanzapine. Olanzapine is currently a mainstay of treatment for psychotic disorders and mania. Its elimination half-life of (ca. 30 h in humans) is appropriate for once-daily oral dosing. Most psychotic and manic-depressive disord ...

The Contractor will develop pharmacodynamic assays for measuring a number of high-priority molecular targets. These assays will be suitable for pre-clinical and clinical testing to allow for rapid evaluation of treatment responses, gauge treatment correspondence to tumor stasis/regression, allow patient stratification for clinical trials and facilitate clinical validation of cancer therapeutics at ...

DESCRIPTION (provided by applicant): BioElectroMed is developing a new medical device called the PulseCure System that utilizes nanosecond pulsed electric fields to eliminate both benign and malignant skin lesions. We have used the PulseCure to treat malignant melanoma and basal cell carcinoma in mice with very high efficacy. With a single, 6-minute treatment using 100 ns pulses, we can trigger co ...

DESCRIPTION (provided by applicant): Despite rapid advances in elucidating the molecular basis of human diseases, an ostensibly more difficult post-genomic challenge is the functional annotation of disease-specific signaling pathways and integration of this information into the development of novel drugs. RNA interference (RNAi) now makes it possible to use large-scale functional genomic strategie ...

DESCRIPTION (provided by applicant): An adequate medical response to the threat of pandemic influenza includes surveillance and isolation, a sufficient supply of effective antiviral drugs, and rapid development of a protective vaccine. Under optimal circumstances, production of enough vaccine to protect the US population would take 6 months. A lag time of 6 months between identification of a pand ...

For divers, out of air situations present a particular hazard. They can result in a dangerous emergency ascent, or failure of a diver to reach the surface. A low air pressure alert (APA) device can provide a valuable margin of safety, but careful design is required. In order for the device to be adopted, it must no t only be effective but it must offer ease of use and a streamlined, erogonomic des ...