Award Data

Having achieved or exceeded all goals and objectives of the Phase I research program, BioScale has thus demonstrated feasibility of a multiplexed, immuno-electromechanical pathogen detection method. In Phase II, BioScale proposes to advance this research by assembling a complete assay system that integrates discrete, commercial off the shelf (COTS) sample preparation subcomponents with the propri ...

Chemical warfare agents such as bis-(b-chloroethyl) sulfide (HD) pose a significant threat to U.S. military and civilian populations. Exposure of skin to HD causes burn-like symptoms such as erythema, edema and severe incapacitating vesication(blistering). To combat this threat, prophylactic and/or therapeutic interventions to HD exposure are needed. Development of such interventions requires an ...

Triton Systems, Inc. proposes a novel sensor system for rapid detection of water-borne chemical and biological warfare agents. Central to Triton's innovation is a

ChemMotif will develop, characterize and evaluate several colorimetric vapor sensors for application as end-of-service-life indicators for carbon-filter gas masks in Chemical and Biological Defense applications. These sensors include two general organicvapor sensors, one of which is sensitive to non-polar organics and the other to polar organics. A third sensor is designed to respond to acid gas ...

The Joint Service Agent Water Monitor (JSAWM) has several challenging operational requirements for detecting and monitoring chemical and biological warfare (CBW) contaminants in water supplies. Surface Enhanced Raman Spectroscopy (SERS) can providespecific spectroscopic

There is a critical need for rapid, accurate measurement of serum cholinesterase activity in the field to provide a timely determination of nerve agent exposure. The overall objective of the project is to develop an easy-to-use analytical system consistingof small, inexpensive (and therefore disposable) silicon microchips used with a portable instrument, thus permitting field cholinesterase measur ...

Physical Sciences Inc. proposes to develop a robust field-deployable assay for detection of biological pathogens (spores, viruses, bacteria) in complex aqueous samples. Our approach involves the combination of several novel technologies for enhancing thesensitivity, specificity, and dynamic range of biological warfare agent (BWA) detection. Integrated into a single assay, these novel components ...

Q-Peak, Inc. proposes to develop a rapidly and broadly tunable, high-average-power, all-solid-state IR source suitable for use as a DIAL system transmitter. The source is based on the combination of a Nd-doped pulsed pump laser and optical parametricoscillators (OPO). The laser source, a compact, quasi-cw diode-pumped, 1 kHz pulse-repetition-rate, passively Q-switched Nd:YLF laser, will pump a tan ...

The early genomic responses of human peripheral blood mononuclear cells (PBMCs) to in vitro infection with specific microbial pathogens are being assessed by DNA microarray technology to determine host gene expression

A thermal infrared imaging spectrometer is proposed for the remote detection and identification of surface contaminants. The instrument will use a high power, pulsing CO2 laser to vaporize the liquids while it scans the target scene generating 3Dspectral-images. The instrument will be pre-programmed with a library of contamination filters that can automatically identify contaminants that could b ...