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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD10102

    To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to advance development of a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses mature components ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  2. 3D Microfluidic Platform for in vitro Hematopoietic Stem Cell (HSC) Culture

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD10103

    Poor drug candidates are often identified late in the drug development process (e.g., in the preclinical and clinical phases) and contribute significantly to the high cost and low yield of drug discovery. As a result, new tools are needed to accelerate the assessment of drug candidate toxicity earlier in the drug development process. To address this Chemical/Bio Defense (CBD) need, Physical Optics ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  3. Next Generation Integrated Electrophoretic Nanofluidic Biochip Sensor Platform for the THz Spectroscopic Finger Printing of Biological Species and Age

    SBC: Redondo Optics, Inc.            Topic: CBD10110

    Redondo Optics Inc. (ROI), proposes to develop and demonstrate a next generation integrated electrophoretic nanofluidic biochip (INTRay-Nanochip) sensor platform for the"label-less"THz spectroscopy finger printing of biological species and agents. In the proposed Phase II of this program, ROI will focus on the engineering development of a manufacturable optical nanolithography technology to enable ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  4. Miniature Residual Life Indicator

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD10106

    To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of determining the degradation in physical adsorption and reactive capacity arising from battlefield contaminants and exposure to the elements, Physical Optics Corporation (POC) proposes to continue the development of a new Miniature Residual Life Indicator (MRLIN). MRLIN is based on impedance spe ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  5. Novel THz-frequency spectrometers by integrating widely-tunable monochromatic THz sources and detectors, or arrays of emitters and detectors, with pho

    SBC: ArkLight            Topic: CBD04104

    By continuing teaming up with one of the most reputable university teams in THz science and technology, ArkLight proposes to carry out the tasks set for a Phase-II program following our success in Phase I. We are aimed at the further development of novel spectrometers to analyze chemicals in the vapor phase based on accurate measurements of the emission and absorption spectra due to the molecular ...

    SBIR Phase II 2005 Department of DefenseOffice for Chemical and Biological Defense
  6. Automatic Assay of Blood Cholinesterase in the Field

    SBC: KUMETRIX, INC.            Topic: N/A

    There is a critical need for rapid, accurate measurement of serum cholinesterase activity in the field to provide a timely determination of nerve agent exposure. The overall objective of the project is to develop an easy-to-use analytical system consistingof small, inexpensive (and therefore disposable) silicon microchips used with a portable instrument, thus permitting field cholinesterase measur ...

    SBIR Phase II 2003 Department of DefenseOffice for Chemical and Biological Defense
  7. Thermal Infrared Surface Contamination Sensor

    SBC: Spectral Imaging Laboratory            Topic: N/A

    A thermal infrared imaging spectrometer is proposed for the remote detection and identification of surface contaminants. The instrument will use a high power, pulsing CO2 laser to vaporize the liquids while it scans the target scene generating 3Dspectral-images. The instrument will be pre-programmed with a library of contamination filters that can automatically identify contaminants that could b ...

    SBIR Phase II 2003 Department of DefenseOffice for Chemical and Biological Defense
  8. Molecular Signatures of Biological Pathogens

    SBC: SUN BIOMEDICAL TECHNOLOGIES            Topic: N/A

    The early genomic responses of human peripheral blood mononuclear cells (PBMCs) to in vitro infection with specific microbial pathogens are being assessed by DNA microarray technology to determine host gene expression

    SBIR Phase II 2003 Department of DefenseOffice for Chemical and Biological Defense

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