Award Data

There is a critical need for rapid, accurate measurement of serum cholinesterase activity in the field to provide a timely determination of nerve agent exposure. The overall objective of the project is to develop an easy-to-use analytical system consistingof small, inexpensive (and therefore disposable) silicon microchips used with a portable instrument, thus permitting field cholinesterase measur ...

The early genomic responses of human peripheral blood mononuclear cells (PBMCs) to in vitro infection with specific microbial pathogens are being assessed by DNA microarray technology to determine host gene expression

A thermal infrared imaging spectrometer is proposed for the remote detection and identification of surface contaminants. The instrument will use a high power, pulsing CO2 laser to vaporize the liquids while it scans the target scene generating 3Dspectral-images. The instrument will be pre-programmed with a library of contamination filters that can automatically identify contaminants that could b ...

This Phase II continuation of ongoing research aims to extend our existing database of human molecular response to infection with biological pathogens. We will compile gene expression changes that are predictive of infection with a larger variety ofbacterial and viral pathogens. The ultimate goal is to perform analyses that may form the basis for a commercial microarray product aimed at early an ...

Threats from microorganisms in the air as a result of natural phenomena or human-induced activities such as terrorism cannot be adequately monitored and evaluated with current technology. Many of the sensor and detector devices that have been underdevelopment for counter-terrorism and chem/biowarfare defense cannot function effectively without an up-front aerosol collector and particle separator. ...