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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Automated Systems for Detection and Molecular Characterization of Circulating Tum

    SBC: ADVANCED CELL DIAGNOSTICS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): The detection and enumeration of circulating tumor cells (CTCs) has the potential to become a very powerful tool in cancer diagnosis and treatment. However, current technologies for CTC detection are not yet established in routine clinical practice. One reason is that CTCs are present in blood at an extremely low concentration of one in 10 million white blood c ...

    SBIR Phase II 2010 Department of Health and Human Services
  2. Handheld IR Raman Spectroscopy for Rapid Chemical Identification

    SBC: Aerius Photonics, LLC.            Topic: CBD08102

    In Phase I, Aerius Photonics demonstrated Raman spectroscopy at 785 nm, 980 nm, and 1064 nm, with only 1064 nm-based excitation showing a reduction in fluorescence. In addition, Aerius Photonics and partner Ahura Scientific, demonstrated a breadboard version of an InGaAs-based Raman spectrometer to assess any engineering challenges. By the end of a Phase III, Aerius proposes to develop a handheld ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  3. Targeted tumoricidal bacteria

    SBC: ANTICANCER, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): We have developed an effective bacterial cancer therapy strategy by targeting viable tumor tissue by using Salmonella typhimurium auxotrophs that we have generated which grow in viable as well as necrotic areas of tumors. However, the auxotrophy severely restricts growth of these bacteria in normal tissue enabling them to be used for cancer treatment. The S. ty ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Liquid Array Protein Assay Platform

    SBC: ARRAYOMICS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The aim of this project is to develop and optimize our novel particle-based microarray platform, ArrayableESP, for application to high multiplex (50- to 2000-plex) proteomic analysis of human serum samples. ESPs are optically-encoded microfabricated particles that can be manipulated using magnetic force. They are manufactured on commercially available photolith ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. Sustained Release Depot Olanzapine

    SBC: AURITEC PHARMACEUTICALS, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): The long-term goal of this research is to minimize morbidity due to non-adherence to outpatient antipsychotic-antimanic therapy with olanzapine. Olanzapine is currently a mainstay of treatment for psychotic disorders and mania. Its elimination half-life of (ca. 30 h in humans) is appropriate for once-daily oral dosing. Most psychotic and manic-depressive disord ...

    SBIR Phase II 2010 Department of Health and Human Services
  6. Not Available

    SBC: BIOASSAY SYSTEMS, LLC            Topic: NCI

    The Contractor will develop pharmacodynamic assays for measuring a number of high-priority molecular targets. These assays will be suitable for pre-clinical and clinical testing to allow for rapid evaluation of treatment responses, gauge treatment correspondence to tumor stasis/regression, allow patient stratification for clinical trials and facilitate clinical validation of cancer therapeutics at ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. DEVELOPMENT OF A NANOSECOND PULSED ELECTRIC FIELD SYSTEM TO TREAT SKIN CANCER

    SBC: BIOELECTROMED CORPORATION            Topic: NCI

    DESCRIPTION (provided by applicant): BioElectroMed is developing a new medical device called the PulseCure System that utilizes nanosecond pulsed electric fields to eliminate both benign and malignant skin lesions. We have used the PulseCure to treat malignant melanoma and basal cell carcinoma in mice with very high efficacy. With a single, 6-minute treatment using 100 ns pulses, we can trigger co ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. Low Cost LWIR Interferometric HSI System

    SBC: Spectrum Photonics, Inc.            Topic: CBD09108

    Due to the potential detection benefits offered by hyperspectral imaging spectroscopy, this is an area of great interest in terms of early detection of plume threats. The major constraint is in costs of components. Under this SBIR, our team will investigate innovative advances in the integration of uncooled microbolometer technologies to determine the potential for reducing detector cost and com ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  9. Functionally Validated Lentiviral siRNA libraries

    SBC: Cellecta, Incorporated            Topic: NCRR

    DESCRIPTION (provided by applicant): Despite rapid advances in elucidating the molecular basis of human diseases, an ostensibly more difficult post-genomic challenge is the functional annotation of disease-specific signaling pathways and integration of this information into the development of novel drugs. RNA interference (RNAi) now makes it possible to use large-scale functional genomic strategie ...

    SBIR Phase II 2010 Department of Health and Human Services
  10. Topical adjuvants to enhance the efficacy of influenza vaccines

    SBC: LANCELL, LLC            Topic: NIAID

    DESCRIPTION (provided by applicant): An adequate medical response to the threat of pandemic influenza includes surveillance and isolation, a sufficient supply of effective antiviral drugs, and rapid development of a protective vaccine. Under optimal circumstances, production of enough vaccine to protect the US population would take 6 months. A lag time of 6 months between identification of a pand ...

    SBIR Phase II 2010 Department of Health and Human Services
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