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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Automated Systems for Detection and Molecular Characterization of Circulating Tum
SBC: ADVANCED CELL DIAGNOSTICS, INC. Topic: NCIDESCRIPTION (provided by applicant): The detection and enumeration of circulating tumor cells (CTCs) has the potential to become a very powerful tool in cancer diagnosis and treatment. However, current technologies for CTC detection are not yet established in routine clinical practice. One reason is that CTCs are present in blood at an extremely low concentration of one in 10 million white blood c ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
Handheld IR Raman Spectroscopy for Rapid Chemical Identification
SBC: Aerius Photonics, LLC. Topic: CBD08102In Phase I, Aerius Photonics demonstrated Raman spectroscopy at 785 nm, 980 nm, and 1064 nm, with only 1064 nm-based excitation showing a reduction in fluorescence. In addition, Aerius Photonics and partner Ahura Scientific, demonstrated a breadboard version of an InGaAs-based Raman spectrometer to assess any engineering challenges. By the end of a Phase III, Aerius proposes to develop a handheld ...
SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense -
New Reagents for Synthesis of High Potency siRNA
SBC: AM BIOTECHNOLOGIES, LLC Topic: NIGMSDESCRIPTION (provided by applicant): New Reagents for Synthesis of High Potency siRNAs Abstract Since the discovery of short interfering RNA (siRNA) molecules in the late 1990s, siRNA technology has developed rapidly as a powerful tool for functional genomic analysis, target validation and therapeutic purposes. However, the potency and persistence of unmodified siRNAs is dramatically limited by th ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
Amplification Strategies for Detection of Fragile X Gene Trinucleotide Repeats
SBC: AMBION DIAGNOSTICS, INC. Topic: NICHDDESCRIPTION (provided by applicant): The overall objective for this project is to develop and implement a comprehensive set of technologies to improve screening and diagnosis of conditions associated with Fragile X Syndrome (FXS). FXS is caused by an expansion of a cytosine-guanine-guanine (CGG) triplet repeat in the 5'-untranslated region of the FMR1 gene. FXS affects 1/4000 men and 1/6000 wo ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
Targeted tumoricidal bacteria
SBC: ANTICANCER, INC. Topic: NCIDESCRIPTION (provided by applicant): We have developed an effective bacterial cancer therapy strategy by targeting viable tumor tissue by using Salmonella typhimurium auxotrophs that we have generated which grow in viable as well as necrotic areas of tumors. However, the auxotrophy severely restricts growth of these bacteria in normal tissue enabling them to be used for cancer treatment. The S. ty ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
Liquid Array Protein Assay Platform
SBC: ARRAYOMICS, INC. Topic: NIAIDDESCRIPTION (provided by applicant): The aim of this project is to develop and optimize our novel particle-based microarray platform, ArrayableESP, for application to high multiplex (50- to 2000-plex) proteomic analysis of human serum samples. ESPs are optically-encoded microfabricated particles that can be manipulated using magnetic force. They are manufactured on commercially available photolith ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
Sustained Release Depot Olanzapine
SBC: AURITEC PHARMACEUTICALS, INC. Topic: NIMHDESCRIPTION (provided by applicant): The long-term goal of this research is to minimize morbidity due to non-adherence to outpatient antipsychotic-antimanic therapy with olanzapine. Olanzapine is currently a mainstay of treatment for psychotic disorders and mania. Its elimination half-life of (ca. 30 h in humans) is appropriate for once-daily oral dosing. Most psychotic and manic-depressive disord ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
Not Available
SBC: BIOASSAY SYSTEMS, LLC Topic: NCIThe Contractor will develop pharmacodynamic assays for measuring a number of high-priority molecular targets. These assays will be suitable for pre-clinical and clinical testing to allow for rapid evaluation of treatment responses, gauge treatment correspondence to tumor stasis/regression, allow patient stratification for clinical trials and facilitate clinical validation of cancer therapeutics at ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
DEVELOPMENT OF A NANOSECOND PULSED ELECTRIC FIELD SYSTEM TO TREAT SKIN CANCER
SBC: BIOELECTROMED CORPORATION Topic: NCIDESCRIPTION (provided by applicant): BioElectroMed is developing a new medical device called the PulseCure System that utilizes nanosecond pulsed electric fields to eliminate both benign and malignant skin lesions. We have used the PulseCure to treat malignant melanoma and basal cell carcinoma in mice with very high efficacy. With a single, 6-minute treatment using 100 ns pulses, we can trigger co ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health -
Unique Anti-microbial Rinse to Reduce Oral Inflammation
SBC: Biomedical Development Corporation Topic: NHLBIDESCRIPTION (provided by applicant): Periodontal disease has been recently identified as a risk factor for increased morbidity and mortality for systemic diseases such as pancreatic cancer, cardiovascular disease (atherosclerosis, myocardial infarction, and stroke), and diabetes, as well as for pregnancy complications such as preterm birth. It is well established that periodontal disease results ...
SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health