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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD10102

    To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to advance development of a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses mature components ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  2. 3D Microfluidic Platform for in vitro Hematopoietic Stem Cell (HSC) Culture

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD10103

    Poor drug candidates are often identified late in the drug development process (e.g., in the preclinical and clinical phases) and contribute significantly to the high cost and low yield of drug discovery. As a result, new tools are needed to accelerate the assessment of drug candidate toxicity earlier in the drug development process. To address this Chemical/Bio Defense (CBD) need, Physical Optics ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  3. Next Generation Integrated Electrophoretic Nanofluidic Biochip Sensor Platform for the THz Spectroscopic Finger Printing of Biological Species and Age

    SBC: Redondo Optics, Inc.            Topic: CBD10110

    Redondo Optics Inc. (ROI), proposes to develop and demonstrate a next generation integrated electrophoretic nanofluidic biochip (INTRay-Nanochip) sensor platform for the"label-less"THz spectroscopy finger printing of biological species and agents. In the proposed Phase II of this program, ROI will focus on the engineering development of a manufacturable optical nanolithography technology to enable ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  4. Miniature Residual Life Indicator

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD10106

    To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of determining the degradation in physical adsorption and reactive capacity arising from battlefield contaminants and exposure to the elements, Physical Optics Corporation (POC) proposes to continue the development of a new Miniature Residual Life Indicator (MRLIN). MRLIN is based on impedance spe ...

    SBIR Phase II 2011 Department of DefenseOffice for Chemical and Biological Defense
  5. Handheld IR Raman Spectroscopy for Rapid Chemical Identification

    SBC: Aerius Photonics, LLC.            Topic: CBD08102

    In Phase I, Aerius Photonics demonstrated Raman spectroscopy at 785 nm, 980 nm, and 1064 nm, with only 1064 nm-based excitation showing a reduction in fluorescence. In addition, Aerius Photonics and partner Ahura Scientific, demonstrated a breadboard version of an InGaAs-based Raman spectrometer to assess any engineering challenges. By the end of a Phase III, Aerius proposes to develop a handheld ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  6. Low Cost LWIR Interferometric HSI System

    SBC: SPECTRUM PHOTONICS, INC.            Topic: CBD09108

    Due to the potential detection benefits offered by hyperspectral imaging spectroscopy, this is an area of great interest in terms of early detection of plume threats. The major constraint is in costs of components. Under this SBIR, our team will investigate innovative advances in the integration of uncooled microbolometer technologies to determine the potential for reducing detector cost and com ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  7. Durable Anti-fog Coatings for Contoured Plastic Substrates Using Nanoparticles with Tunable Size and Surface Chemistry

    SBC: Innosense Llc            Topic: CBD09101

    Currently fielded respiratory protective systems in the Joint Services General Purpose Mask (JSGPM) program degrade in visual performance capability in extreme hot and cold environments. Optical and mechanical properties of existing anti-fog coatings also diminish when subjected to cleaning/sanitization operations. To address these needs, InnoSense LLC (ISL), in Phase I, has combined nanomaterials ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  8. An Enhanced Quarter-Sized Optical NEMS Based Methyl Salicylate Sensor System (MS3)

    SBC: IMAGINATIVE TECHNOLOGIES, LLC            Topic: CBD09103

    Building on our successful Phase I work our Phase II objectives are to complete development and integration of our two proposed sensors into an unprecedented self-confirming MeS detection system further refining our ability to meet key requirements identified in Phase I. More specifically, we will develop a NEMS based MeS sensor system complete with a telemetry system and/or a remote logging, data ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  9. Dielectrophoretic Microfluidic Protein Analysis System

    SBC: PHYSICAL OPTICS CORPORATION            Topic: CBD09104

    To address the U.S. Army CBD need for a low-cost, universal, robust, and fieldable device for rapid, reproducible identification of protein variants from biological samples with high throughput, Physical Optics Corporation (POC) proposes to develop a new Dielectrophoretic Microfluidic Protein Analysis (DiMiPA) system based on an electrodeless dielectrophoresis-based, continuous-flow protein separa ...

    SBIR Phase II 2010 Department of DefenseOffice for Chemical and Biological Defense
  10. Automatic Assay of Blood Cholinesterase in the Field

    SBC: KUMETRIX, INC.            Topic: N/A

    There is a critical need for rapid, accurate measurement of serum cholinesterase activity in the field to provide a timely determination of nerve agent exposure. The overall objective of the project is to develop an easy-to-use analytical system consistingof small, inexpensive (and therefore disposable) silicon microchips used with a portable instrument, thus permitting field cholinesterase measur ...

    SBIR Phase II 2003 Department of DefenseOffice for Chemical and Biological Defense

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