Award Data

To address the CBD need for improved formulations to enhance the ease of use and bioavailability of antisense therapeutics, Physical Optics Corporation (POC) proposes to advance development of a Multifunctional Antisense Therapeutics Nanocarrier and Inhalation Device (MATEN). This proposed system is based on a new dry powder formulation and a novel design of an inhaler that uses mature components ...

Poor drug candidates are often identified late in the drug development process (e.g., in the preclinical and clinical phases) and contribute significantly to the high cost and low yield of drug discovery. As a result, new tools are needed to accelerate the assessment of drug candidate toxicity earlier in the drug development process. To address this Chemical/Bio Defense (CBD) need, Physical Optics ...

Longwave infrared (LWIR, 8-12µm) focal plane arrays (FPAs) play an important role in hyperspectral chemical and biological (CB) sensing and spectral imaging. Existing thermal detectors are unable to meet the high sensitivity and fast response requirements of many hyperspectral chemical and biological sensing applications. FPAs based on photon excited electron generation process can fulfill the sp ...

To address the Chemical and Biological Defense (CBD) need for a residual life indicator (RLI) capable of determining the degradation in physical adsorption and reactive capacity arising from battlefield contaminants and exposure to the elements, Physical Optics Corporation (POC) proposes to continue the development of a new Miniature Residual Life Indicator (MRLIN). MRLIN is based on impedance spe ...

Leveraging on Agiltron industry leading development of optical MEMS devices and the PI experience with FTIR spectrometer design, we propose to develop a new class of high performance compact and rugged FTIR spectrometers for the LWIR optical range. The design is based on the MEMS lamellar mirror technique. Although this approach is not new, it has not yet been efficiently applied to LWIR, and per ...

Redondo Optics Inc. (ROI), proposes to develop and demonstrate a next generation integrated electrophoretic nanofluidic biochip (INTRay-Nanochip) sensor platform for the"label-less"THz spectroscopy finger printing of biological species and agents. In the proposed Phase II of this program, ROI will focus on the engineering development of a manufacturable optical nanolithography technology to enable ...

In Phase I, Aerius Photonics demonstrated Raman spectroscopy at 785 nm, 980 nm, and 1064 nm, with only 1064 nm-based excitation showing a reduction in fluorescence. In addition, Aerius Photonics and partner Ahura Scientific, demonstrated a breadboard version of an InGaAs-based Raman spectrometer to assess any engineering challenges. By the end of a Phase III, Aerius proposes to develop a handheld ...

Due to the potential detection benefits offered by hyperspectral imaging spectroscopy, this is an area of great interest in terms of early detection of plume threats. The major constraint is in costs of components. Under this SBIR, our team will investigate innovative advances in the integration of uncooled microbolometer technologies to determine the potential for reducing detector cost and com ...

Currently fielded respiratory protective systems in the Joint Services General Purpose Mask (JSGPM) program degrade in visual performance capability in extreme hot and cold environments. Optical and mechanical properties of existing anti-fog coatings also diminish when subjected to cleaning/sanitization operations. To address these needs, InnoSense LLC (ISL), in Phase I, has combined nanomaterials ...

Building on our successful Phase I work our Phase II objectives are to complete development and integration of our two proposed sensors into an unprecedented self-confirming MeS detection system further refining our ability to meet key requirements identified in Phase I. More specifically, we will develop a NEMS based MeS sensor system complete with a telemetry system and/or a remote logging, data ...