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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Genetic Assay for Inhibitors of RNA-Protein Interactions


    RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses including HIV, hepatitis C, SARS, and West Nile virus, and thus represent attractive targets for therapeutics. We have developed novel cell-based assays to identify drugs that target the RNA-protein interactions. The assays incorporate a system of genetic reporters to acc ...

    STTR Phase II 2005 Department of Health and Human Services
  2. High Resolution Digital Imaging X-ray Detectors

    SBC: Aguila Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim is to develop a high resolution, high contrast detector for digital x-ray imaging systems. The target detector would have a Detective Quantum Efficiency much greater than 80%, a limiting resolution of at least 10 lp/mm, ultra-low noise, linear response and a dynamic range of more than 14 bits. The proposal is to build such a detector by using CdZnTe c ...

    STTR Phase II 2005 Department of Health and Human Services
  3. Development of Vasoactive Therapeutic

    SBC: Azerx, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Approximately 30,000 patients per year in the US suffer from subarachnoid hemorrhage (SAH). Although SAH represents only 5-10% of strokes, its impact is proportionally much higher because SAH patients are typically younger (mean age is 50 years) than other stroke patients. Nearly half of SAH patients die from either the initial hemorrhage or secondary compli ...

    STTR Phase II 2005 Department of Health and Human Services
  4. Safety of Lung Delivered Tissue Plasminogen Activator

    SBC: HTD Biosystems Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The acute respiratory distress syndrome (ARDS) represents a significant health hazard that is associated with high morbidity and mortality rates. Unfortunately, little progress has been made in advancing the treatment of ARDS. Phase I STTR funding supported the successful determination of a feasible formulation of tissue plasminogen activator (tPA) for pulmona ...

    STTR Phase II 2005 Department of Health and Human Services
  5. Image-Guided Minimally Invasive Robotic Surgery

    SBC: INTUITIVE SURGICAL            Topic: N/A

    DESCRIPTION (provided by applicant): Image-guided surgery allows surgeons to specifically target diseased tissue while sparing healthy tissue, reducing morbidity and improving patient outcomes. Minimally invasive surgical techniques deliver specific intervention without the morbidity associated with large open incisions. Image-guidance technology has the potential to provide significant benefit ...

    STTR Phase II 2005 Department of Health and Human Services
  6. Numerical Algorithms for Steady and Unsteady Multi-Disciplinary Simulation of Flight Vehicles

    SBC: Intelligent Aerodynamics            Topic: T201

    Industry is driven by the cost of man-power and time to market, and is still awaiting a versatile and reliable multi-disciplinary analysis code. The proposed JFLO software suite addresses many aspects that are still not totally resolved in current state-of- the-art CFD. It will enable optimal designs as well as the multi-disciplinary application of CFD for digital flight. The key elements of JFLO ...

    STTR Phase II 2005 National Aeronautics and Space Administration
  7. Space Qualified Non-Destructive Evaluation and Structural Health Monitoring Technology

    SBC: Nextgen Aeronautics, Inc.            Topic: T702

    Encouraged by Phase I accomplishments, the proposed Phase II program will significantly mature and align the development of a Space Qualified Non-Destructive Evaluation & Health Monitoring system with the needs of NASA. We are systematically working to improve the TRL to 5 at the end of Phase II and formulate commercialization and product development strategy beyond Phase II. The proposed health ...

    STTR Phase II 2005 National Aeronautics and Space Administration
  8. High Volume, Low-Cost Production Process for High-grade Silicon Carbide Optics


    The following proposal summarizes the process by which Trex will utilize out patented CVC (Chemical Vapor Composite) SiC process to fabricate near net shape lightweight SiC mirrors with high as-deposited optical surface quality. In the first task of this program, Trex will continue our development program to optimize the as-deposited surface quality of our CVC SiC. We have selected several diffe ...

    STTR Phase II 2005 National Aeronautics and Space Administration
  9. Automated Behavioral Health Triage

    SBC: Activity Research Services            Topic: A04T025

    The overall objective of this project is to develop an automatic adaptive testing system that rapidly identifies specific cognitive deficits to aid in medical and operational decision making. The Phase I effort produced a prototype adaptive triage system. ANAMts, designed to automatically focus testing on specific cognitive domains. ANAMts consists of a 4-level adaptive cognitive testing system ...

    STTR Phase II 2005 Department of DefenseArmy
  10. Multi-functional nanocomposite materials with high-temperature polymer resin matrice

    SBC: Sensintel Inc.            Topic: AF03T018

    The overall objective of the proposed Phase II STTR program is to continue optimization of properties already obtained during Phase I which established the feasibility of concept to multi-functionality for BMI polymer matrix composites along with structural capability. Throughout this 2-year effort, it is proposed to seek optimization of the composite properties. The goal is develop and demonstrat ...

    STTR Phase II 2005 Department of DefenseAir Force

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