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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Error Reduction in Dipole-Source Localization Models

    SBC: ABRATECH CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): We are developing means to reduce errors in Dipole Source Localization (DSL). DSL is commonly used to analyze brain waves for clinical and research purposes. It is known from our work and the work of others that the models used to compute the DSL are not perfect, but it is not known how much the imperfect models affect the solutions obtained. Based upon our ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  2. Healthy Dining Finder Restaurant Logo and Website Program

    SBC: ACCENTS ON HEALTH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of Healthy Dining Finder is to help reduce the prevalence of risk factors related to obesity and nutrition-related diseases by increasing the availability of, and information about, healthier meals at restaurants nationwide. With the cooperation of the National Restaurant Association, Accents On Health, Inc. (dba Healthy Dining) will approac ...

    SBIR Phase II 2005 Department of Health and Human ServicesCenters for Disease Control and Prevention
  3. Genetic Assay for Inhibitors of RNA-Protein Interactions

    SBC: ADVANCED GENETIC SYSTEMS, INC.            Topic: N/A

    RNA-protein interactions play critical roles in cellular regulatory processes and in the life cycles of many pathogenic viruses including HIV, hepatitis C, SARS, and West Nile virus, and thus represent attractive targets for therapeutics. We have developed novel cell-based assays to identify drugs that target the RNA-protein interactions. The assays incorporate a system of genetic reporters to acc ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  4. High throughput screen of behavior using piezo-imaging

    SBC: AFASCI, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Neurobehavioral assessments, including arousal activity level and sleep pattern, are endpoints of global nervous system function. Virtually all pathological conditions, particularly neuropsychological disorders such as anxiety and depression, and a variety of different classes of drugs, can lead to the alteration of behavior and disturbance of sleep. Although a ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  5. High Resolution Digital Imaging X-ray Detectors

    SBC: Aguila Technologies, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim is to develop a high resolution, high contrast detector for digital x-ray imaging systems. The target detector would have a Detective Quantum Efficiency much greater than 80%, a limiting resolution of at least 10 lp/mm, ultra-low noise, linear response and a dynamic range of more than 14 bits. The proposal is to build such a detector by using CdZnTe c ...

    STTR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  6. Treatment of Pain by Drug Aerosol Inhalation

    SBC: Alexza Molecular Delivery Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Breakthrough pain is a feared symptom afflicting the majority of cancer patients at some point in their illness. It is characterized by rapid onset, with pain intensity reaching excruciating level within several minutes, and brief duration (median duration approximately 30 minutes). Although commonly used, due to their delayed onset and long duration of action ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  7. Gamma Secretase Assays to Discover Drugs for Alzheimer's

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a long-term, debilitating disorder that causes loss of memory and cognitive functions. There is an urgent need for effective therapeutic agents to ameliorate the symptoms of AD. Important molecular drug targets in AD are the gamma-secretases that produce the neurotoxic Abeta peptides in AD. The regulated secretory pathway of neurons ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  8. Novel Method to Produce Beta-Amino Acids

    SBC: BIOCATALYTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Beta-Amino acids are rapidly growing in importance as a key class of pharmaceutical intermediates, with applications in a number of current and future drugs. A cost-effective process for the production of optically pure beta-amino acids will be developed in this project to accommodate the commercial needs for beta-amino acids. The method involves two enzymati ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  9. UDP-Glucuronic Acid Regeneration System

    SBC: BIOCATALYTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Glucuronidation is a major metabolic pathway for the inactivation and detoxification of endogenous and exogenous compounds in the human body. Glucuronides are formed by a super family of uridine diphosphoglucuronosyl transferases (UGTs) that convert a number of lipophilic xenobiotics (drugs, steroids, pollutants and pesticides) into more hydrophilic species by ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
  10. Diagnostic aid software for the visual field test

    SBC: BIOFORMATIX, INC.            Topic: N/A

    Visual field (VF) test is a widely used, noninvasive technique for evaluating pathology or dysfunction in the visual pathways. The VF test, in conjunction with other diagnostics, is used for detection of laucoma and for following its progression. Early detection is critical as blindness from glaucoma is preventable in nearly all cases, provided treatment is administered early in the progression. ...

    SBIR Phase II 2005 Department of Health and Human ServicesNational Institutes of Health
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