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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Tolerability of SRX246 in Huntington's Disease Patients

    SBC: AZEVAN PHARMACEUTICALS INC            Topic: 950

    DESCRIPTIONprovided by applicantHuntington s DiseaseHDis an inherited disease that results from expansion of a trinucleotideCAGcytosine adenine guaninerepeat that encodes a polyglutamine tract in the huntingtin proteinPsychiatric symptomsincluding irritability and aggressionare common in HD patientsThese are among the most distressing aspects of the diseaseThey have adverse effects on daily life a ...

    SBIR Phase II 2016 Department of Health and Human Services
  2. CATHEPSIN L INHIBITORS AS PAN CORONAVIRUS THERAPEUTICS

    SBC: PHELIX THERAPEUTICS LLC            Topic: R

    DESCRIPTION provided by applicant Coronaviruses CoV are RNA viruses that cause gastrointestinal respiratory and neurological symptoms in several mammalian species The outbreak of the severe acute respiratory syndrome CoV SARS CoV in humans was fatal in of infected patients infecting people and killing The recent incidents involving the highly pathogenic Middle East ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  3. Virtual Bone Biopsy: Transfer to the clinical arena

    SBC: MICROMRI, INC.            Topic: N/A

    Osteoporosis is a major community health problem for which several effective FDA approved therapies exist, but which remains largely undiagnosed and untreated. While bone densitometry using dual-energy x-ray absorptiometry (DXA) is the current "gold standard" in osteoporosis diagnosis, controlled clinical trials have highlighted its sensitivity and specificity limitations at the individual patient ...

    SBIR Phase II 2005 Department of Health and Human Services
  4. Wave Detection, Prediction, and Reaction System (WDPRS)

    SBC: DANIEL H. WAGNER ASSOCIATES, INCORPORATED            Topic: N10AT036

    In this Phase II SBIR project, Daniel H. Wagner Associates (DHWA), with NASAs Jet Propulsion Laboratory (JPL), MARK Resources, Inc. (MRI), and Spatial Integrated Systems (SIS) as our subcontractors, will develop a prototype lightweight, low-cost Wave Detection, Prediction, and Reaction System (WDPRS), and then test and evaluate its performance at-sea. The proposed WDPRS is designed to reduce the h ...

    SBIR Phase II 2013 Department of DefenseNavy
  5. Advancement to Clinical Candidate of Novel, Potent and Selective Chikungunya virus inhibitor series

    SBC: VenatoRx Pharmaceuticals, Inc.            Topic: NIAID

    DESCRIPTIONprovided by applicantNovel therapies for the treatment of Chikungunya virusCHIKVinfections are urgently needed to address the alarming spread of this pathogen across the AmericasWe have identified a series of potentselectiveand orally bioavailable inhibitors of CHIKV replicationIn this Direct to Phaseprojectwe will optimize this series of CHIKV inhibitors to Pre Development stage and ad ...

    SBIR Phase II 2016 Department of Health and Human Services
  6. Harvesting Electric Power from Walking

    SBC: LIGHTNING PACKS LLC            Topic: N06T026

    Combat units operating on foot in remote regions are highly dependent on electrical energy for communications, navigation and sensing. As the use of electronic devices on the battlefield increases, so will the need for electrical energy independence. At present, power is provided by carrying a large weight of batteries (as much as 20 lbs), which when added to their usual 80-lb packs, represents ...

    STTR Phase II 2008 Department of DefenseNavy
  7. Improved High Power Diode Array Manufacturing

    SBC: SIMMTEC, INC.            Topic: MDA02021a

    The primary objective of this proposed Phase II Project is to scale up the SiMMtec diode array manufacturing process and to demonstrate that the target price of $3/W for QCW operation for high performance high power diode arrays can be achieved for 1000 array orders. We propose to develop and demonstrate the scale up of the required processes to fabricate the SiMM array. Extended lifetest of the ...

    SBIR Phase II 2004 Department of DefenseMissile Defense Agency
  8. Low Antigenicity Factor VIII

    SBC: Octagen Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Octagen's broad, long-term objective is to complete the clinical development and secure FDA approval of its b-domain deleted recombinant factor VIII (OBI-1), a low antigenicity version of factor VIM (fVIII). OBI-1 is designed for the treatment of patients with inhibitory, neutralizing antibodies to human fVIII. Such "inhibitor" patients include congenital hemop ...

    SBIR Phase II 2005 Department of Health and Human Services
  9. DEVELOPMENT OF TOPICAL ANTIVIRAL AGENTS FOR TREATING MOLLUSCUM CONTAGIOSUM

    SBC: Fox Chase Chemical Diversity Center, Inc.            Topic: NIAID

    DESCRIPTIONprovided by applicantMolluscum contagiosumMCis a highly contagious skin disease caused by the poxvirusMCVMC appears as lesions on the body and face and can last months years before resolvingLesions occur most frequently in childrenand immune compromised individualsThe infection is confined to skin aloneit is not systemicTransmission spreads directly from person person contactautoinocula ...

    SBIR Phase II 2016 Department of Health and Human Services
  10. Novel HBV Therapeutic with Potential for Treatment of Drug-Resistant Infection

    SBC: Pharmabridge, Inc.            Topic: NIAID

    DESCRIPTION (provided by applicant): This is a Phase II proposal to advance development of disubstituted tetrahydro-triazolo-pyrimidines (TTPs) as specific inhibitors of hepatitis B virus surface antigen (HBsAg) secretion in chronic infection. High serum levels of HBsAg (antigenemia) are believed to underlie immunotolerance toward the infection. Although they are clinically beneficial, the current ...

    SBIR Phase II 2011 Department of Health and Human Services

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